Hypofractionated Radiotherapy for Soft Tissue Sarcomas
This study is looking at a new way to treat soft tissue sarcomas (cancers that form in the soft tissues of the body, like muscle, fat, or nerves). It tests two different schedules of pre-operative radiation, called Ultra-Hypo-fractionation Radiotherapy (5 days of radiation) or Moderately-Hypo-fractionation Radiotherapy (15 days of radiation), followed by surgery (Resection). This approach aims to shorten the radiation treatment time compared to the usual 5-week course, without increasing problems with wound healing or the cancer coming back. The main goal is to see how well the cancer is controlled locally (Local control rate) after about 2 years. You might be able to join if you have a soft tissue sarcoma in an arm, leg, pelvis, chest wall, or trunk/abdominal wall, are at least 18 years old, and are healthy enough for radiation and surgery. The study is currently unclear on its recruitment status.
- Study design
- This is an interventional study where patients are assigned to one of two groups for radiation treatment before surgery. It plans to enroll 40 participants.
- What's involved
- You would receive either 5 or 15 daily radiation treatments, followed by surgery. You would also complete questionnaires for ancillary studies.
- Compensation
- Not stated in the trial record.
- Follow-up
- After treatment, you would have follow-up visits within 3 months, then every 3-6 months for at least 2 years.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Hypofractionated Radiotherapy Followed by Surgical Resection in the Treatment of Soft Tissue Sarcomas
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Eric Shinohara, MD · PRINCIPAL_INVESTIGATOR · Vanderbilt Medical Center
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Local control rateApproximately 2 years
Will be estimated with a Beta-Binomial model with Beta(0.5, 0.5) as the prior distribution. The median and a 95% credible interval of the posterior distribution will be reported.