Skeletal Health in Adolescents with Crohn Disease
This observational study is looking at bone health in adolescents (ages 13-20) newly diagnosed with Crohn's disease (CD) compared to healthy adolescents. Researchers want to understand if CD leads to more fat in bone marrow, which could affect bone strength. They will use special MRI scans (Coronal T1 weighted spin echo images, Spin-lattice relaxation (T1) relaxometry, Magnetic resonance spectroscopy) to look at your bones and take blood samples to check markers related to bone formation and breakdown. The main goal is to see if adolescents with new CD diagnoses have increased bone marrow fat and how that relates to bone mineral density over one year. You can join if you've been diagnosed with Crohn's disease within the last 3 months, or if you are a healthy control, and do not have other conditions or medications that affect bone health.
- Study design
- This is an observational study comparing 46 adolescents with newly diagnosed Crohn's disease to 46 healthy adolescents.
- What's involved
- You would undergo MRI scans and blood draws at the beginning of the study and again after one year.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed for one year after their initial assessments.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Skeletal Health and Bone Marrow Composition in Newly Diagnosed Adolescents With Crohn Disease
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Rebecca Gordon, MD · PRINCIPAL_INVESTIGATOR · Boston Children's Hospital
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Bone marrow adiposity by magnetic resonance imaging (MRI)Baseline and One Year follow-up
Change in Bone marrow adiposity measured by MRI (T1 maps)
- Magnetic resonance spectroscopy (MRS)Baseline and One Year follow-up
Change in T2 corrected fat/(fat+ water) ratios