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Study of OPM and SQUID Sensors for Epilepsy

This study is testing a new type of sensor called an optically-pumped magnetometer (OPM) for detecting epileptic seizures. These OPM sensors work at room temperature and are being compared to the current standard, SQUID sensors, which require very cold temperatures. Researchers want to see if OPM sensors can provide clearer brain images and be more practical for long-term monitoring. This could potentially offer a less invasive way to map seizures than current methods. The study is looking for adults aged 18-70, including healthy volunteers and patients with epilepsy. The goal is to show that OPM sensors are not only more economical and easier to use but also improve signal quality for brain imaging.

Study design
This interventional study plans to enroll 40 participants. It compares OPM sensors to SQUID sensors for brain imaging.
What's involved
Participants will have a brain scan on one day using both OPM and SQUID sensors.
Compensation
Not stated in the trial record.
Follow-up
Participants will be assessed during a single day for their brain scan.

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NCT04515316

A Room Temperature Atomic Magnetrode System for Telemetry of Epileptic Seizures

UNKNOWN
NAAges 18–70InterventionalDiagnostic
University of Colorado, Denver
~40 participants
Updated 2024-05-16 on ClinicalTrials.gov
What's tested:OPM sensorsSQUID sensors

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Evoked and Induced MEG with OPM and SQUID sensors in healthy controls
Measured over 1 day (during the brain scan)
+1 more outcome measured

Conditions

Epilepsy

Explore related trials

Seizure Disorder

Where it's being run

1 sites across 1 states
Colorado1

Who to contact

Isabelle Buard, PhD
[email protected]
303-724-5973
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Project A: Any adult subject, who is at least eighteen (18 - 70) years old.
Project B: Any clinical patient referred to us via the clinical MEG program, and who is at least eighteen (18 - 70) years old.

Exclusion

ONLY applicable to Project A: have a history of neurological disorders (e.g., epilepsy, Parkinson disease, Alzheimer's disease, Autism, etc…).
BOTH projects: have large amounts of metal or other magnetic field producing components present in their body or external to their body close to the measurement site, which are needed for normal functioning (e.g., metal implants, pacemakers, hearing aids, braces etc.). There is no harm to the subject with metal, it disturbs the sensor reading. Dental fillings are not excluded.
BOTH projects: pregnant women.
ONLY applicable to Project A: are not comfortable lying still for the time of the recording.
BOTH projects: are unable to offer independent informed consent to study participation.

What this trial measures

  • Evoked and Induced MEG with OPM and SQUID sensors in healthy controls1 day (during the brain scan)

    compare our own and published findings related to sensory-evoked brain activity using SQUIDs with results obtained with OPMs using the same paradigm and environment.

  • Spontaneous MEG with OPM and SQUID sensors in patients with epilepsy1 day (during the brain scan)

    compare the clinical findings related to the localization of interictal spike activity obtained during SQUID recordings as part of our clinical program with results from OPMs data collection on the same patients.