Observational Study on Glomerular Disease and Bone Health

This observational study aims to understand how glomerular disease (a type of kidney disease) affects the strength and quality of your bones. Researchers will use imaging techniques like DXA scans (Dual-energy X-ray absorptiometry) and HR-pQCT (High Resolution Peripheral Quantitative Computed Tomography) to measure bone strength in your arms and legs. They will also collect blood and urine samples, and ask you to complete questionnaires about your health, diet, and activity. The study is looking for children and adults aged 5 to 55 years who have been diagnosed with glomerular disease. The main goal is to see how bone strength changes over 12 months in people with this condition.

Study design
This is an observational study with a planned enrollment of 270 participants. It is not a treatment study, but rather aims to understand the impact of glomerular disease on bone health.
What's involved
You would have imaging scans (DXA and HR-pQCT), blood draws, urine collections, and complete questionnaires at the beginning of the study and again after 12 months.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 12 months, with assessments at baseline and the 12-month visit.

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NCT04528446

The Impact of Glomerular Disorders on Bone Quality and Strength

UNKNOWN
Not specifiedAges 5–55Observational
Columbia University
~270 participants
Updated 2024-07-01 on ClinicalTrials.gov
What's tested:Dual-energy X-ray absorptiometryHigh Resolution Peripheral Quantitative Computed Tomography (HR-pQCT)Blood draw and Urine collectionQuestionnaires

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in radius bone strength (failure load)
Measured over Baseline and 12 months
+1 more outcome measured
Glomerular Disease
Bone Diseases, Metabolic
Bone Fracture
2 sites across 2 states
New York1
Pennsylvania1
  • Thomas L. Nickolas, MD · PRINCIPAL_INVESTIGATOR · Columbia University

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  • Change in radius bone strength (failure load)Baseline and 12 months

    HR-pQCT will be used to assess bone microarchitecture and generate micro-finite element analysis (µFEA)-based estimates of bone strength.

  • Change in tibia bone strength (failure load)Baseline and 12 months

    HR-pQCT will be used to assess bone microarchitecture and generate micro-finite element analysis (µFEA)-based estimates of bone strength.