Observational Study on Glomerular Disease and Bone Health
This observational study aims to understand how glomerular disease (a type of kidney disease) affects the strength and quality of your bones. Researchers will use imaging techniques like DXA scans (Dual-energy X-ray absorptiometry) and HR-pQCT (High Resolution Peripheral Quantitative Computed Tomography) to measure bone strength in your arms and legs. They will also collect blood and urine samples, and ask you to complete questionnaires about your health, diet, and activity. The study is looking for children and adults aged 5 to 55 years who have been diagnosed with glomerular disease. The main goal is to see how bone strength changes over 12 months in people with this condition.
- Study design
- This is an observational study with a planned enrollment of 270 participants. It is not a treatment study, but rather aims to understand the impact of glomerular disease on bone health.
- What's involved
- You would have imaging scans (DXA and HR-pQCT), blood draws, urine collections, and complete questionnaires at the beginning of the study and again after 12 months.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed for 12 months, with assessments at baseline and the 12-month visit.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
The Impact of Glomerular Disorders on Bone Quality and Strength
At a glance
Conditions
Where it's being run
2 sites across 2 statesStudy leadership
- Thomas L. Nickolas, MD · PRINCIPAL_INVESTIGATOR · Columbia University
Who to contact
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What this trial measures
- Change in radius bone strength (failure load)Baseline and 12 months
HR-pQCT will be used to assess bone microarchitecture and generate micro-finite element analysis (µFEA)-based estimates of bone strength.
- Change in tibia bone strength (failure load)Baseline and 12 months
HR-pQCT will be used to assess bone microarchitecture and generate micro-finite element analysis (µFEA)-based estimates of bone strength.