Observational Study of Accelerated MRI for Knee Conditions
This observational study is looking at new ways to use MRI (Magnetic Resonance Imaging) to better understand knee conditions like osteoarthritis (OA) and ACL tears. Currently, OA is often diagnosed late, and this study aims to find earlier signs of cartilage damage using advanced MRI techniques called T1ρ and T2 relaxometry. The study is testing new, faster MRI methods to make these scans more practical for doctors and patients. Researchers also want to see how consistent these MRI measurements are across different hospitals and MRI machines. You may be able to join if you are between 18 and 50 years old, whether you are healthy, have an acute ACL tear, or have had ACL reconstruction. The study aims to enroll 88 participants.
- Study design
- This is an observational study with no specified phase, meaning participants are observed without receiving a specific intervention. It plans to enroll 88 participants.
- What's involved
- Not specified in the trial record.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed for knee MRI measurements for 1-2 years, site reproducibility for 2-3 years, and ACL tear and reconstruction for 3-5 years.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Multi-Vendor Multi-Site Novel Accelerated MRI Relaxometry
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Xiaojuan Li · PRINCIPAL_INVESTIGATOR · Director, Program for Advanced Musculoskeletal Imaging
Who to contact
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What this trial measures
- Knee MRIYear 1-2
Knee MRI will be collected at the 3T scanner (Prisma) at CCF. One time point. The MRI exam time will be two hours per subject including set up. No questionnaires will be required.
- Site reproducibilityYear 2-3
Knee MRI will be collected at three 3T scanners at CCF (Siemens, GE, Philips), and three scanners at UCSF, University of Kentucky and Albert Einstein College of Medicine, respectively. The three scans at CCF can be on the same day or on different days, but all six scans need to take place within 2 months to minimize potential physiologic variations.To evaluate the reproducibility, subjects will be scanned and then rescanned during one visit on the same day for each of the six scans.
- ACL tear and reconstructionYear 3-5
Knee MRI at three 3T scanners at CCF (Siemens, GE, Philips). For patients, the ACL injured and reconstructed knee will be scanned. For controls, to scan which side of the knee (left or right) will be based on subjects' preference. If the subject has no reference, the dominant leg will be scanned. At each time point, the three scans can be on the same day or on different days, but all the three scans need to take place within 2 weeks to minimize potential physiologic variations. For patients with ACL tear and reconstruction, surgical report (including graft type, surgeon recorded lesions) will also be collected.