PET Detection of CCR2 in Human Atherosclerosis

This study is testing a new radioactive imaging medicine called 64CU-DOTA-ECL1i. It aims to see how well this medicine can help doctors visualize atherosclerosis (a condition where plaque builds up inside your arteries) in the carotid and femoral arteries. The study is looking for healthy volunteers aged 18-40, and patients aged 50-89 with known carotid artery atherosclerosis who may or may not be having surgery. The main goal is to evaluate the imaging characteristics of 64CU-ECL1i. The current recruitment status is unclear, but the study plans to enroll 100 participants.

Study design
This interventional study plans to enroll 100 participants. It involves two groups: one for those having surgery and healthy volunteers, and another for those not having surgery.
What's involved
If you are in Group 1, you will have one imaging session lasting about 60 minutes. If you are in Group 2, you will have two imaging sessions 7-14 days apart.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint, evaluation of imaging characteristics, is measured at 1 or 2 days.

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NCT04537403

PET Detection of CCR2 in Human Atherosclerosis

Recruiting
PHASE1Ages 18–89InterventionalDiagnostic
Washington University School of Medicine
~100 participants
Updated 2025-08-01 on ClinicalTrials.gov
What's tested:Group 1-64CU-DOTA-ECL1i (radioactive imaging medicine)Group 2 64CU-DOTA-ECL1i (radioactive imaging medicine)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Evaluation of 64CU-ECL1i , imaging characteristics
Measured over 1 or 2 days
Carotid Atherosclerosis
1 sites across 1 states
Missouri1

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  • Evaluation of 64CU-ECL1i , imaging characteristics1 or 2 days

    Injecting normal volunteers and patients who have blocked arteries with a single bolus injection. The dose of the injection is 8-10, and the above drug is measured in millicuries, which is a unit of radioactivity. the dose of millicuries will be 8-10 millicures