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Stress and Congestive Heart Failure Study

This study is looking at how stress affects people with congestive heart failure (CHF). Researchers want to see if stress can make CHF worse. You would undergo mental stress activities in a lab and also use a special device (ecological momentary assessment or EMA) in your daily life to measure how stress and emotions impact your pulmonary artery pressure (PAP), which is the pressure in the blood vessels leading from your heart to your lungs. The study will also look at how changes in PAP due to stress relate to CHF flare-ups. This study is for people aged 18 and older who have congestive heart failure and already have or will be getting a CardioMEMS PAP monitor. The main goal is to measure your pulmonary artery pressure after 6 months. The current status of this study is unclear.

Study design
This is an interventional study with a planned enrollment of 112 participants. It is not specified if the study is randomized or blinded.
What's involved
You would be followed for 6 months, participating in lab mental stress tasks and using an EMA device. You will also complete questionnaires about your well-being.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 6 months.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT04551560

Stress and Congestive Heart Failure

Completed
NAAges 18+InterventionalBasic science
Yale University
~108 participants
Updated 2026-08-18 on ClinicalTrials.gov
What's tested:Mental Stress

At a glance

Recruiting sites
0 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Pulmonary Artery Pressure
Measured over 6 months

Conditions

Congestive Heart Failure

Explore related trials

Congestive Heart Failure

Where it's being run

2 sites across 1 states
Connecticut2

Study leadership

  • Rachel Lampert, MD · PRINCIPAL_INVESTIGATOR · Yale University

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Heart failure patients over 18 who have or will be receiving a Cardiomems implanted PAP monitor.

Exclusion

Patients who are unable to perform EMA or laboratory assessments due to cognitive, visual, language, or other disabilities will be excluded.
Patients with Class IV heart failure will also be excluded, as they are already maximally decompensated, and a ceiling/floor effect would preclude effects of stress.
Patients with conditions other than heart failure that affect PA pressures (e.g. dialysis).
Patients with physical conditions that interfere with study participation.
Patients non-compliant with their PAP monitoring.
Patients with chronic opioid use will be excluded.

What this trial measures

  • Pulmonary Artery Pressure6 months

    Pulmonary artery pressure as measured by an implanted monitor: Pulmonary artery pressure will be compared between times of stress and calm, in both the laboratory and real-life setting.