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Exercise Therapy for Metastatic Prostate Cancer

This study, called EXERT, is looking at whether personalized exercise therapy can improve the quality of life and physical functioning for men with prostate cancer that has spread (metastatic prostate cancer) who are receiving radiation therapy. You might be able to join if you are a man aged 18 or older with lymph node positive or metastatic prostate cancer and are receiving radiation therapy. The study aims to see if exercise therapy helps reduce side effects and improve how you feel, and if it might even improve survival. Researchers will measure your quality of life at 12 weeks after treatment to see if the exercise therapy is successful. The current status of this study is unclear.

Study design
This is an interventional study with a planned enrollment of 80 participants. It compares personalized exercise therapy to not receiving personalized exercise therapy.
What's involved
If assigned to the exercise therapy group, you will receive a personalized exercise regimen for 4 weeks, including in-person supervised sessions and activities to do at home.
Compensation
Not stated in the trial record.
Follow-up
Your quality of life will be measured at 12 weeks after treatment.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT04556045

Exercise Therapy and Radiation Therapy (EXERT) for Metastatic Prostate Cancer

Active, Not Recruiting
NAAges 18+InterventionalSupportive care
Case Comprehensive Cancer Center
~80 participants
Updated 2026-05-07 on ClinicalTrials.gov
What's tested:Exercise therapy

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Quality of life using the Patient-Reported Outcomes Measurement Information System (PROMIS Scale v1.2-Global Health)
Measured over At 12 week follow up

Conditions

Malignant Neoplasm of Prostate

Explore related trials

Prostate Carcinoma

Where it's being run

1 sites across 1 states
Ohio1

Study leadership

  • Angela Jia, MD, PhD · PRINCIPAL_INVESTIGATOR · University Hospitals Cleveland Medical Center, Case Comprehensive Cancer Center

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Subjects must have lymph node positive or metastatic disease consistent with prostate cancer
Males ≥18 years of age receiving RT
Patient receiving 5 fractions or stereotactic body radiation therapy (SBRT)
Patient may have received prior hormone therapy. Prior or current use of chemotherapy agents is allowed, but not necessary.
Fluent in written and spoken English
Must be able to provide and understand informed consent
Must have an ECOG Performance Status (PS) of ≤ 3
Primary attending radiation oncologist approval

Exclusion

Performing \> 90 minutes/week of exercise therapy prior at time of enrollment
Evidence in the medical record of an absolute contraindication for exercise
Class II, III or IV heart failure as defined by the New York Heart Association (NYHA) functional classification system
History of acute coronary syndromes (including myocardial infarction and unstable angina), coronary angioplasty or stenting within the past 6 months prior to the start of radiation therapy
Uncontrolled arrhythmias; patients with rate-controlled atrial fibrillation for \>1 month prior to start of radiation therapy may be eligible
syncope
acute myocarditis, pericarditis, or endocarditis
acute pulmonary embolus or pulmonary infarction
thrombosis of lower extremities
suspected dissecting aneurysm
pulmonary edema
respiratory failure
acute non-cardiopulmonary disorder that may affect exercise performance or be aggravated by exercise
Mental impairment leading to inability to complete study requirements
In-patient receiving radiation therapy for a radiation emergency (e.g. cord compression, Superior vena cava (SVC) syndrome, brain metastases)
High risk of fracture or spine instability (Mirels score ≥7, SINS ≥7)
Children (the protocol will only include men age 18 and older)

What this trial measures

  • Quality of life using the Patient-Reported Outcomes Measurement Information System (PROMIS Scale v1.2-Global Health)At 12 week follow up

    Patient Reported Outcome Measurement Information System (PROMIS) Global Health v1. 2 short form is a 10-item instrument representing multiple domains. Scores are assigned for both Global Physical Health component and Global Mental Health component. The response scores range from 1-5, where 1 = always and 5 = Never. A higher score from responses indicate better health.