Scleral Lens Fitting Using Wide-Field OCT for Corneal Conditions

This study is looking at whether a special imaging technology called OCT (Optical Coherence Tomography) can help improve how scleral contact lenses are fitted. Scleral lenses are larger contact lenses that rest on the white part of your eye (sclera) and are often used for conditions like keratoconus (a thinning of the cornea), or after eye surgeries like corneal transplants (post-penetrating keratoplasty or PK), LASIK (post-LASIK ectasia), or RK (post-radial keratotomy). Researchers will compare a standard lens fitting to one guided by OCT. Success will be measured by how well the lens fits, looking at things like how much space there is between the lens and your eye (apical and limbal clearance), and if the lens is pressing too hard on your eye (conjunctival compression). You may be able to join if you are 18 or older and need scleral lenses for certain eye conditions, but you cannot have other eye diseases that might affect your vision.

Study design
This is an observational study planning to enroll 258 participants. It compares two different methods of fitting scleral lenses.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary outcomes, such as apical clearance, limbal clearance, and conjunctival compression, will be measured at 5 years.

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NCT04570020

Scleral Lens Fitting Using Wide-Field OCT

Recruiting
Not specifiedAges 18+Observational
Oregon Health and Science University
~258 participants
Updated 2025-09-09 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Apical Clearance
Measured over 5 years
+3 more outcomes measured
Keratoconus
Irregular; Contour of Cornea
1 sites across 1 states
Oregon1
  • David Huang, MD, PhD · PRINCIPAL_INVESTIGATOR · Oregon Health and Science University

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Eligibility criteria

Inclusion

Eyes requiring fit for scleral lenses for KCN, post-PK, post-RK, post-LASIK ectasia, or various anterior surface disorders

Exclusion

Inability to maintain stable fixation for OCT imaging
Inability to commit to required visits to complete the study
Eyes with concurrent retinal diseases, glaucoma, or other eye conditions that may limit visual outcome
  • Apical Clearance5 years

    Apical clearance of each lens (whether clinically-selected or OCT-selected) will be graded as "acceptable," "too high," or "too low."

  • Limbal Clearance5 years

    Limbal clearance of each lens (whether clinically-selected or OCT-selected) will be graded as "acceptable," "too much," or "too little."

  • Conjunctival Compression5 years

    Conjunctival compression of each lens (whether clinically-selected or OCT-selected) will be graded as "acceptable" or "excessive."

  • Lens Edge Lift5 years

    Lens edge lift for each lens (whether clinically-selected or OCT-selected) will be graded as "acceptable" or "excessive."