Periarticular Injection Versus Popliteal Block for Foot and Ankle Surgery

This study is comparing two common ways to manage pain after foot or ankle surgery: a periarticular injection of Exparel, or a popliteal block using Bupivicaine. Researchers want to see which method is more effective and safer for controlling pain after hindfoot or ankle osteotomy (bone cutting), fusion, or ankle fracture repair. You may be able to join if you are between 18 and 80 years old, having one of these surgeries at Campbell Surgery Center, and can speak and read English. The study will measure pain levels using a Visual Analog Score and check for motor block (muscle weakness) at 3 and 6 hours after surgery to see how well each treatment works. The current status of this study is unclear.

Study design
This is a randomized, controlled study comparing two pain management methods. About 100 participants are planned for this study.
What's involved
You would need to comply with study instructions and attend all follow-up visits for the duration of the study.
Compensation
Not stated in the trial record.
Follow-up
Pain levels and motor block will be measured at 3 and 6 hours after surgery.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT04575688

Periarticular Injection Versus Popliteal Block

Enrolling by Invitation
PHASE4Ages 18–80InterventionalTreatment
Campbell Clinic
~100 participants
Updated 2025-12-24 on ClinicalTrials.gov
What's tested:ExparelBupivicaine

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Visual Analog Score
Measured over Postoperative hour 3
+10 more outcomes measured
Foot Surgery
Ankle Surgery
1 sites across 1 states
Tennessee1
  • Garnett A Murphy, MD · PRINCIPAL_INVESTIGATOR · Campbell Clinic

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Ankle or hindfoot osteotomy or ankle fracture repair
Surgery scheduled at Campbell Surgery Center (1410 Brierbrook Road, Germantown, TN 38138)
18-80 years of age
ASA I-III with medical clearances as needed
Fluent ub verbal and written English
Willing and able to comply with study instruction and commit to all follow-up visits for theduration of the study
Willing and able to provide written consent

Exclusion

Diagnosed with chronic pain syndrome
History of allergic reactions to lidocaine, marcaine, Experal, bupivicaine, or other injectable anesthetic agents
Injury associated with workers' compensation
Surgery to be performed at a hospital
Diagnosed with peripheral neuropathy
Hbg A1C is \> 7 mg/dl in diabetic patients only
Long term (chronic) preoperative narcotic usage
  • Visual Analog ScorePostoperative hour 3

    Patient reported pain score from zero to ten where zero is no pain and ten is the most pain

  • Evidence of motor blockPostoperative hour 3

    Patient reported yes/no answer to survey question: "Are you able to wiggle your toes?"

  • Visual Analog ScorePostoperative hour 6

    Patient reported pain score from zero to ten where zero is no pain and ten is the most pain

  • Visual Analog ScorePostoperative hour 12

    Patient reported pain score from zero to ten where zero is no pain and ten is the most pain

  • Visual Analog ScorePostoperative hour 24

    Patient reported pain score from zero to ten where zero is no pain and ten is the most pain

  • Visual Analog ScorePostoperative hour 36

    Patient reported pain score from zero to ten where zero is no pain and ten is the most pain

  • Visual Analog ScorePostoperative hour 48

    Patient reported pain score from zero to ten where zero is no pain and ten is the most pain

  • Visual Analog ScorePostoperative hour 72

    Patient reported pain score from zero to ten where zero is no pain and ten is the most pain

  • Visual Analog ScorePostoperative week 2

    Patient reported pain score from zero to ten where zero is no pain and ten is the most pain

  • Visual Analog ScorePostoperative week 4-6

    Patient reported pain score from zero to ten where zero is no pain and ten is the most pain

  • Visual Analog ScorePostoperative week 12

    Patient reported pain score from zero to ten where zero is no pain and ten is the most pain