Understanding Flu Vaccine Immunity in COVID-19 Patients

This study aims to understand how well the flu vaccine works in people who have had COVID-19. Researchers will give all participants a single flu shot and then measure their immune response (how their body fights off infection) one week and one month later. They are looking for adults and children aged 9 to 64 who have had COVID-19, including those with conditions like obesity, diabetes, chronic fatigue, or long-term COVID-19 symptoms. People who have not had COVID-19 can also join as a comparison group. The study is currently unclear on its recruitment status, but plans to enroll 230 participants.

Study design
This is an observational study planning to enroll 230 participants. All participants will receive a single flu shot.
What's involved
All participants will receive a single flu shot. Their immunity to the flu vaccine will be tested at one week and one month after the shot.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for one month after receiving the flu vaccine to test their immunity.

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NCT04579588

Understanding Immunity to the Flu Vaccine in COVID-19 Patients

Recruiting
Not specifiedAges 9–64Observational
Stanford University
~230 participants
Updated 2026-03-18 on ClinicalTrials.gov
What's tested:Flu shot

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Testing immunity to the flu vaccine over time
Measured over 1 week
+1 more outcome measured
Corona Virus Infection
Flu Vaccine
Immunity
1 sites across 1 states
California1
  • Sayantani Sindher, MD · PRINCIPAL_INVESTIGATOR · Stanford University

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Eligibility criteria

Inclusion

Age 9 through 64 years
Diagnosed with COVID-19 at least 2 months prior enrollment
Patients with or without obesity, diabetes, chronic fatigue and/or long term COVID-19 symptoms
Patients without COVID-19 diagnosis for controls

Exclusion

Received the influenza vaccine less than 4 months ago
Pregnant or lactating
Patients with special risks attendant to venipuncture
Use of immunomodulatory medications that may impact vaccine immune response per clinician's judgment
Contraindication to the flu vaccine
Immunodeficiency or autoimmune disease that may impact vaccine immune responses per clinician's judgement
  • Testing immunity to the flu vaccine over time1 week
  • Testing immunity to the flu vaccine over time1 month