Corneal Biomechanical Analysis Using Brillouin Microscopy

This observational study is looking at how stiff your cornea (the clear front part of your eye) is, using a special device called Brillouin microscopy. Researchers want to understand how corneal stiffness changes in people with keratoconus (a condition where the cornea thins and bulges) and after certain eye procedures like LASIK or corneal cross-linking (CXL). The study will measure changes in corneal stiffness over three months. You might be able to join if you are between 18 and 60 years old and have keratoconus, normal corneas, or are having refractive surgery (like LASIK) or CXL for keratoconus. The study aims to enroll 220 participants.

Study design
This is an observational study, meaning researchers will be watching and recording information without giving you a specific treatment. It plans to include 220 participants.
What's involved
The study will measure changes in Brillouin metrics between your baseline visit and 3 months later. The specific number of visits or procedures is not detailed.
Compensation
Not stated in the trial record.
Follow-up
Your corneal stiffness will be measured at baseline and again 3 months later.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT04598932

Corneal Biomechanical Analysis Using Brillouin Microscopy

Enrolling by Invitation
Not specifiedAges 18–60Observational
The Cleveland Clinic
~220 participants
Updated 2026-02-17 on ClinicalTrials.gov
What's tested:Brillouin microscopy

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in Brillouin Metrics
Measured over Difference between baseline and 3 months after intervention
Keratoconus
Keratoconus, Unstable
Keratoconus, Stable
1 sites across 1 states
Ohio1

This trial hasn't published a contact. View it on ClinicalTrials.gov

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Eligibility criteria

Inclusion

patients aged 18-60 with keratoconus
patients aged 18-60 with normal corneas,
patients aged 18-60 undergoing refractive surgery (LASIK, PRK, SMILE)
patients aged 18-60 with keratoconus undergoing CXL

Exclusion

outside age range
history of previous ocular surgeries
unable to cooperate for the Brillouin microscopic examination
unable to provide informed consent
  • Change in Brillouin MetricsDifference between baseline and 3 months after intervention

    Brillouin metrics to be evaluated include localized Mean Brillouin modulus measure across the cornea and at each depth of the corneal stroma