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Deep Brain Stimulation for Parkinson's Disease

This study is looking at how Deep Brain Stimulation (DBS) of two brain areas, the pedunculopontine nucleus (PPN) and the subthalamic nucleus (STN), affects attention, walking, and balance in people with Parkinson's disease. You might be able to join if you are between 18 and 75 years old, have had Parkinson's for at least 4 years, and experience tremors, motor complications, or gait instability with falls. The study will involve surgery to implant electrodes in your brain. Researchers will measure how STN-PPN stimulation affects your risk of falling over 27 months. The current status of this study is unclear, and it plans to enroll 8 participants.

Study design
This is a prospective, single-center randomized controlled trial. Participants will be randomized to receive either bilateral STN+PPN stimulation or bilateral STN stimulation alone.
What's involved
You would undergo bilateral STN DBS surgery, with additional leads placed in the PPN. The primary outcome will be measured at 27 months.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint, STN-PPN Stimulation Effect on Fall Risk, will be measured at 27 months.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT04605263

Deep Brain Stimulation (DBS) of the Pedunculopontine Nucleus (PPN)

Enrolling by Invitation
NAAges 18–75InterventionalTreatment
St. Joseph's Hospital and Medical Center, Phoenix
~8 participants
Updated 2024-11-29 on ClinicalTrials.gov
What's tested:STN-PPN DBS SurgeryDeep Brain Stimulation Surgery (DBS)

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
STN-PPN Stimulation Effect on Fall Risk
Measured over 27 months

Conditions

Parkinson Disease

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Parkinson Disease

NCT04605263

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • St. Joseph's Hospital & Medical Center / Barrow Neurological Institute

    Phoenix, Arizonano site contact published

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Guillermo Moguel-Cobos, MD · PRINCIPAL_INVESTIGATOR · Muhammad Ali Movement Disorders Clinic Physician

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

What this trial measures

  • STN-PPN Stimulation Effect on Fall Risk27 months

    The purpose of this study is to measure the effect and the mechanism of deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) on fall risk as established by quantitative gait and balance analysis.