Liver Transplantation for Cirrhosis and Acute-on-Chronic Liver Failure

This observational study is looking at liver transplantation (LT) in patients with severe liver disease. It aims to understand the best times to consider LT for people with cirrhosis (scarring of the liver) and acute-on-chronic liver failure (ACLF, a sudden worsening of long-term liver disease). Researchers will compare the survival rates after LT in patients with different levels of ACLF, and also look at patients who don't receive a transplant. The study will follow participants for one year. You may be able to join if you are 18 to 80 years old, have liver cirrhosis, and have been hospitalized for a sudden worsening of your liver condition. The study is currently unclear on its recruitment status.

Study design
This is an observational study involving 3000 participants. It compares different groups of patients with liver disease.
What's involved
Participants will be followed for one year after liver transplantation, or for one year after joining the study if they are not listed for transplant.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for one year after liver transplantation or after inclusion in the study.

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NCT04613921

Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure: iNdications and outComEs

Recruiting
Not specifiedAges 18–80Observational
European Foundation for Study of Chronic Liver Failure
~3,000 participants
Updated 2025-10-20 on ClinicalTrials.gov
What's tested:Observational Protocol

At a glance

Recruiting sites
69 of 106 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Survival
Measured over 1 year
Liver Diseases
Liver Cirrhosis
Acute-On-Chronic Liver Failure
Liver Transplant; Complications
106 sites across 45 states
Germany13
France9
India7
Spain7
Italy5
Japan5
United Kingdom5
New York3

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Eligibility criteria

Inclusion

1\. Male or female subject ≥18 years of age.
Group 1: patients listed for liver transplantation with ACLF-2 or 3 at the time of listing or developing ACLF 2-3 while on the waiting list.
Group 2: patients listed for liver transplantation with decompensated cirrhosis without ACLF-2 or 3 and poor liver function (MELD\>20) at the time of listing.
Group 3: patients having ACLF-2 or 3, are assessed for inclusion in the waiting list, but are finally not listed for liver transplantation.
  • Survival1 year

    survival