Developing Brain, Impulsivity and Compulsivity Study
This study is looking at how impulsivity (acting without thinking) and compulsivity (being overly inflexible) are connected to brain development and genetics. Researchers want to understand why people have different levels of these behaviors, especially in conditions like Obsessive Compulsive Disorder, Conduct Disorder, Attention Deficit Hyperactivity Disorder, and Autism Spectrum Disorder. They will measure a brain chemical called glutamate using Magnetic Resonance Spectroscopy (a type of brain scan) and look at how much of this is passed down through families. This is an observational study, meaning there are no interventions or treatments being tested. It aims to enroll 1100 participants between 6 and 80 years old. The current status of the study is unclear.
- Study design
- This is an observational study that plans to enroll 1100 participants. It uses a longitudinal design to study development over time and a twin design to look at how traits are inherited.
- What's involved
- You will have a medical history taken and your medical records reviewed. You will talk about your mental and behavioral development, including topics like drug use and sexual activity, and complete surveys about impulsivity and compulsivity. Glutamate concentration will be measured yearly if possible.
- Compensation
- Not stated in the trial record.
- Follow-up
- Glutamate concentration will be measured yearly if possible, but the overall duration of follow-up is not specified.
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Developing Brain, Impulsivity and Compulsivity
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Tonya J White, M.D. · PRINCIPAL_INVESTIGATOR · National Institute of Mental Health (NIMH)
Who to contact
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What this trial measures
- Glutamate concentration measured using Magnetic Resonance SpectroscopyYearly if possible
Age-related change in cortical glutamate levels and its moderation by individual differences in levels of impulsivity and compulsivity.
- Heritability of cortical glutamate (proportion of variance explained by additive genetic factors).Baseline
Degree to which glutamate levels are under genetic control.