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Cognitive Status After Skull Base Meningioma Removal

This study is looking at how surgery for a meningioma (a type of brain tumor) in the frontal or temporal lobes affects your thinking and memory over time. Researchers will use standard cognitive tests, like the RBANS tests, MoCA, PROMIS-29, and NeuroQOL-Cognitive Functions, to see how your cognitive function changes after surgery. You could be eligible if you are 18 to 89 years old, have a meningioma in the frontal or temporal lobe, and are scheduled for open craniotomy or Endoscopic Endonasal surgery. The main goal is to understand your overall cognitive function 12 months after surgery. The current status of this study is unclear.

Study design
This is an observational study involving 50 participants. It will compare cognitive function at different time points.
What's involved
You would undergo standard cognitive testing at baseline (before surgery), six weeks after surgery, and one year after surgery.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 12 months after surgery to assess overall cognitive function.

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NCT04635657

Cognitive Status After Removal of Skull Base Meningioma

Recruiting
Not specifiedAges 18–89Observational
Ohio State University
~50 participants
Updated 2026-05-22 on ClinicalTrials.gov
What's tested:Long-term Cognitive testing

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Overall cognitive function
Measured over 12 months

Conditions

Meningioma
Skull Base Meningioma
Frontal Meningioma
Temporal Meningioma
Cognitive Impairment
Cognitive Decline
Post-Surgical Cognition

Explore related trials

Meningioma

Where it's being run

1 sites across 1 states
Ohio1

Study leadership

  • Daniel Prevedello, MD · PRINCIPAL_INVESTIGATOR · Ohio State University

Who to contact

Emma Kurtz, BS
[email protected]
(614) 685-4534
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Subject has a meningioma associated with the frontal or temporal lobes
Subject is scheduled to undergo open craniotomy or Endoscopic Endonasal surgery
Subject is 18 years of age or older
The subject must in the investigator's opinion, be psychosocially, mentally, and physically able to fully comply with this protocol including the required follow-up visits, the filling out of required forms, and have the ability to understand and give written informed consent
Previous surgery will not exclude the patient as a new baseline cognitive evaluation will occur.

Exclusion

Patient is a prisoner
Patient is 90 years of age or older
Pregnant women
Previous radiation to the brain

What this trial measures

  • Overall cognitive function12 months

    Cognitive function will be compared at baseline and at one year post-operatively.