This study is for people aged 18 and older who have been diagnosed with achalasia or another esophageal motility disorder. It aims to understand achalasia better by looking at how your lower esophageal sphincter (the muscle at the bottom of your esophagus) responds to an Atropine challenge. Researchers will use a special tool called a functional lumen imaging probe (FLIP) to measure muscle contraction and relaxation after you receive intravenous Atropine. They will also collect a small muscle biopsy during a planned surgery (Heller myotomy or per-oral endoscopic myotomy) to examine the collagen content. The goal is to learn more about achalasia so it can be treated earlier. This study plans to enroll 80 participants, but its current status is unclear.

Study design

This is an interventional study planning to enroll 80 participants. It involves specific procedures and measurements.

What's involved

You would receive intravenous Atropine, have FLIP measurements taken before and after, and undergo an esophageal muscle biopsy during a planned surgery.

Compensation

Not stated in the trial record.

Follow-up

Measurements for the primary endpoints are taken two minutes after the study drug administration.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.