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Localizing Epileptic Networks Using MRI and iEEG

This study is looking for people with epilepsy that hasn't responded to medication, especially those with suspected temporal lobe epilepsy, who are already planning to have intracranial EEG (iEEG) placement. Researchers are using different types of MRI scans (3T and 7T Magnetic Resonance Imaging) along with iEEG recordings to understand how epilepsy networks work in the brain. The goal is to find better ways to use non-invasive imaging to predict how well epilepsy surgery will work and to guide where electrodes are placed for iEEG. This could lead to less invasive and more targeted treatments for epilepsy. The study is currently unclear on its recruitment status and plans to enroll 290 participants.

Study design
This interventional study plans to enroll 290 participants. It is not specified if it is randomized or blinded.
What's involved
You would undergo 3T and 7T Magnetic Resonance Imaging scans. Intracranial electroencephalography (iEEG) recordings would also be taken, which you are already planned to receive.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint, structure-function coupling, will be assessed upon collection of your pre-implant MRI study and iEEG recordings.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT04649008

Localizing Epileptic Networks Using MRI and iEEG

Recruiting
EARLY_PHASE1Ages 18+InterventionalDiagnostic
University of Pennsylvania
~290 participants
Updated 2026-02-13 on ClinicalTrials.gov
What's tested:3T Magnetic Resonance ImagingIntracranial electroencephalography recordings7T Magnetic Resonance Imaging

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Structure-function coupling
Measured over Measure will be assessed upon collection of patient pre-implant MRI study and iEEG recordings, and control MRI

Conditions

Epilepsy
Epilepsy Intractable
Epilepsy, Temporal Lobe

Explore related trials

Temporal Lobe Epilepsy

Where it's being run

1 sites across 1 states
Pennsylvania1

Study leadership

  • Kathryn A Davis, MD, MSTR · PRINCIPAL_INVESTIGATOR · University of Pennsylvania

Who to contact

Kathryn A Davis, MD, MSTR
[email protected]
215-349-5166
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Patients with medication-refractory epilepsy
Planned intracranial EEG (IEEG) placement
Hypothesized to have temporal lobe epilepsy

Exclusion

Contraindication to 3T MRI (e.g. metal implants or claustrophobia), clinical features that typically preclude the use of IEEG (e.g. pregnancy), prior intracranial surgery or device, and IEEG findings that are non-diagnostic (e.g. seizure onset zone(s) not identified)

What this trial measures

  • Structure-function couplingMeasure will be assessed upon collection of patient pre-implant MRI study and iEEG recordings, and control MRI

    This study aims to analyze MRI and iEEG to quantify structure-function coupling (SC-FC), specifically between white matter connections and IEEG, across preictal and ictal periods in consecutive patients undergoing IEEG monitoring with SEEG targeting the temporal lobe networks at the University of Pennsylvania and Medical University of South Carolina.