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Comparing Alkalinizing Agents for Kidney Stone Risk

This study aims to compare different treatments that help prevent kidney stones. Researchers are looking at how well potassium citrate, sodium bicarbonate, Litholyte (a dietary supplement), Crystal Lite (lemonade), and potassium bicarbonate change your urine to reduce stone formation. The study will measure changes in your urine volume and creatinine levels. You may be eligible to join if you are an adult aged 18 to 90, with or without a history of kidney stones. The study is looking for 15 participants. The goal is to find more affordable and accessible options to prevent kidney stones.

Study design
This is an interventional study with a planned enrollment of 15 participants. The study compares several different alkalinizing agents.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Urine measurements are taken at baseline (Day 4), initial start of treatment (Day 5), and end of study (Day 12).

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT04651088

Comparing Alkalinizing Agents Efficacy on Stone Risk in Patients on a Metabolically Controlled Diet

Not Yet Recruiting
EARLY_PHASE1Ages 18–90InterventionalPrevention
University of Texas Southwestern Medical Center
~15 participants
Updated 2026-02-13 on ClinicalTrials.gov
What's tested:Potassium citrateSodium bicarbonateLitholyteCrystal LitePotassium Bicarbonate

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
24 hour urine volume
Measured over Change from baseline (Day 4) to initial start on treatment (Day 5)
+25 more outcomes measured

Conditions

Kidney Stone

Explore related trials

Nephrolithiasis

Where it's being run

1 sites across 1 states
Texas1

Who to contact

Brett A Johnson, MD
[email protected]
214-648-6853
Email the study team

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Eligibility criteria

Inclusion

Adults aged 18 and older.
with or without a history of stone disease.

Exclusion

They are unable to take any of the medications due to health reasons.
Participants are pregnant or nursing.
Participants are unable to adhere to the metabolic diet.
Participants had a prior adverse event from one or more of the medications.

What this trial measures

  • 24 hour urine volumeChange from baseline (Day 4) to initial start on treatment (Day 5)

    Total urine volume

  • 24 hour urine volumeChange from baseline (Day 4) to end of study (day 12)

    Total urine volume

  • 24 hour urine creatinineChange from baseline (Day 4) to initial start on treatment (Day 5)

    Urine creatinine

  • 24 hour urine creatinineChange from baseline (Day 4) to end of study (day 12)

    Urine creatinine

  • 24 hour urine calciumChange from baseline (Day 4) to initial start on treatment (Day 5)

    urine calcium

  • 24 hour urine calciumChange from baseline (Day 4) to end of study (day 12)

    urine calcium

  • 24 hour urine potassiumChange from baseline (Day 4) to initial start on treatment (Day 5)

    Urine potassium

  • 24 hour urine potassiumChange from baseline (Day 4) to end of study (day 12)

    Urine potassium

  • 24 hour urine sodiumChange from baseline (Day 4) to initial start on treatment (Day 5)

    Urine sodium

  • 24 hours urine sodiumChange from baseline (Day 4) to end of study (day 12)

    Urine sodium

  • 24 hours urine citrateChange from baseline (Day 4) to initial start on treatment (Day 5)

    Urine citrate

  • 24 hours urine citrateChange from baseline (Day 4) to end of study (day 12)

    Urine citrate

  • 24 hours urine uric acidChange from baseline (Day 4) to initial start on treatment (Day 5)

    Urine uric acid

  • 24 hours urine uric acidChange from baseline (Day 4) to end of study (day 12)

    Urine Uric Acid

  • 24 hours urine oxalateChange from baseline (Day 4) to initial start on treatment (Day 5)

    Urine oxalate

  • 24 hours urine oxalateChange from baseline (Day 4) to end of study (day 12)

    Urine oxalate

  • 24 hours urine magnesiumChange from baseline (Day 4) to initial start on treatment (Day 5)

    Urine magnesium

  • 24 hours urine magnesiumChange from baseline (Day 4) to end of study (day 12)

    Urine magnesium

  • 24 hours urine ammoniaChange from baseline (Day 4) to initial start on treatment (Day 5)

    Urine ammonia

  • 24 hours urine ammoniaChange from baseline (Day 4) to end of study (day 12)

    Urine ammonia

  • 24 Hour Urine pHChange from baseline (Day 4) to initial start on treatment (Day 5)

    Overal Urine pH from 24h urine sample.

  • 24 Hour Urine pHChange from baseline (Day 4) to end of study (day 12)

    Overal Urine pH from 24h urine sample.

  • 24 hour urine phosphorusChange from baseline (Day 4) to initial start on treatment (Day 5)

    Urine phosphorus

  • 24 hour urine phosphorusChange from baseline (Day 4) to end of study (day 12)

    Urine phosphorus

  • 24 hour urine sulfateChange from baseline (Day 4) to initial start on treatment (Day 5)

    Urine sulfate

  • 24 hour urine sulfateChange from baseline (Day 4) to end of study (day 12)

    Urine sulfate