This observational study is looking at how exercise affects levels of cell-free DNA (AlloSure) in people who have had a heart transplant. Researchers want to see if strenuous exercise, like that done during a cardiopulmonary exercise test (CPET), changes the amount of AlloSure in your blood. This information could help doctors understand the best time to test AlloSure levels and if exercise affects the accuracy of the test. The study is open to heart transplant patients aged 18 and older who can safely exercise on a treadmill or bike. Success would mean understanding if AlloSure levels are stable after exercise or if exercise can make the test more sensitive for detecting issues. The current recruitment status is unclear.

Study design

This is an observational study with a planned enrollment of 27 participants. It is not a randomized or blinded study.

What's involved

You would undergo a cardiopulmonary exercise test (CPET) with EKG. AlloSure testing will be done at baseline, then at 1 hour, 4 hours, 1 day, and 7 days after the CPET.

Compensation

Not stated in the trial record.

Follow-up

Your cell-free DNA and oxygen consumption levels will be compared up to 10 days after the exercise test.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.