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Personalized Surveillance for Duodenal and Gastric Polyps in FAP

This study is looking at a personalized surveillance and intervention protocol for people with Familial Adenomatous Polyposis (FAP). FAP is a genetic condition that causes many polyps (growths) in the colon and can also lead to polyps in the stomach and small intestine (duodenum). The goal is to see how well this personalized approach works to prevent advanced neoplasia (pre-cancerous or cancerous growths) in the stomach and duodenum. You may be able to join if you are 18 or older and have a diagnosis of FAP. This study plans to enroll about 1000 participants. The current status of the study is unclear.

Study design
This is an observational study, meaning researchers will watch and collect information about participants. It involves one group of participants and plans to enroll 1000 people.
What's involved
Participants will have endoscopic surveillance (a procedure using a camera to look inside the body) every 3 months to 5 years, depending on the severity of their polyps and any procedures they've had.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for up to 5 years to see if advanced neoplasia develops.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT04677998

A Personalized Surveillance and Intervention Protocol for Duodenal and Gastric Polyposis in Patients With Familial Adenomatous Polyposis

Recruiting
Not specifiedAges 18+Observational
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
~1,000 participants
Updated 2026-02-23 on ClinicalTrials.gov
What's tested:Personalized surveillance and intervention protocol

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Advanced neoplasia
Measured over Up to 5 years

Conditions

Familial Adenomatous Polyposis

Explore related trials

Familial Adenomatous Polyposis

NCT04677998

Where you'd take part

This study runs at 2 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Academic Medical Centre

    Amsterdam, North Holland, Netherlandsstudy coordinator listed

    Recruiting

  • MD Anderson

    Houston, Texasstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Who to contact

Annie Lincoln
[email protected]
+1 919 923 4430
Email the study team

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Eligibility criteria

Inclusion

Diagnosis of FAP, at least one of following: genetic diagnosis (proven APC germline mutation) and/or clinical diagnosis (\>100 colorectal adenomas in combination with a positive family history of FAP)
Age 18 years or older

Exclusion

Endoscopic removal of all polyps with an indication for removal not possible/feasible
Gastric or duodenal cancer at baseline endoscopy
Need for surgery

What this trial measures

  • Advanced neoplasiaUp to 5 years

    Incidence of advanced neoplasia defined as adenomas ≥15mm, high grade dysplasia (HGD) and/or duodenal/ampullary cancer