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Personalized Surveillance for Familial Adenomatous Polyposis After Surgery

This study is looking at a personalized plan for monitoring and treating patients with Familial Adenomatous Polyposis (FAP) who have already had surgery to remove their colon or part of it (proctocolectomy or colectomy). FAP is a condition where many polyps grow in the colon and rectum, which can lead to cancer. The study wants to see how well this personalized plan works to prevent advanced polyps from developing over up to 5 years. You may be able to join if you are 18 or older, have a diagnosis of FAP (either genetic or clinical), and have had a prophylactic (preventative) colectomy or proctocolectomy. The study aims to enroll 1000 participants.

Study design
This is an observational study, meaning participants will be monitored without receiving a specific experimental treatment. It involves one group of participants undergoing endoscopic surveillance.
What's involved
Participants will have endoscopic surveillance (a procedure using a camera to look inside the body) every 6 months to 2 years, depending on the severity of their polyps and previous procedures.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for up to 5 years to see if advanced polyps develop.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT04678011

A Personalized Surveillance and Intervention Protocol for Patients With Familial Adenomatous Polyposis That Have Undergone (Procto)Colectomy

Recruiting
Not specifiedAges 18+Observational
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
~1,000 participants
Updated 2026-02-23 on ClinicalTrials.gov
What's tested:Personalized surveillance and intervention protocol

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Advanced neoplasia
Measured over Up to 5 years

Conditions

Familial Adenomatous Polyposis

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NCT04678011

Where you'd take part

This study runs at 2 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Academic Medical Centre

    Amsterdam, North Holland, Netherlandsstudy coordinator listed

    Recruiting

  • MD Anderson

    Houston, Texasstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Who to contact

Annie Lincoln
[email protected]
+1 919 923 4430
Email the study team

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Eligibility criteria

Inclusion

Diagnosis of FAP, at least one of following: genetic diagnosis (proven APC germline mutation) and/or clinical diagnosis (\>100 colorectal adenomas in combination with a positive family history of FAP)
Have undergone prophylactic (procto)colectomy with IRA/ISA or IPAA
Age 18 years or older

Exclusion

Not able to remove all polyps with an indication for removal during (multiple) clearing endoscopies
Cancer at baseline endoscopy
Need for surgery

What this trial measures

  • Advanced neoplasiaUp to 5 years

    Incidence of advanced neoplasia (advanced adenoma and cancer). An advanced adenoma is defined as size ≥ 10mm and/or high-grade dysplasia. This surveillance and intervention protocol will be considered successful when the incidence of advanced neoplasia is less than 5% after a study period of 5 years.