Cardiogenic Shock Working Group Registry

This study is an observational registry for patients experiencing cardiogenic shock (a severe condition where your heart can't pump enough blood to meet your body's needs). Researchers are collecting information from medical records and follow-up phone calls about how patients with cardiogenic shock are treated with medications like vasopressors (phenylephrine, norepinephrine, epinephrine, dopamine, vasopressin) and inotropes (dobutamine, milrinone), as well as devices like ECMO, Impella, and IABP. The goal is to understand how these treatments affect patient outcomes, specifically looking at death rates 30 days and one year after leaving the hospital. You may be eligible if you are 18 years or older and have cardiogenic shock, defined by specific heart measurements. The study aims to enroll 5000 participants, but its current status is unclear.

Study design
This is an observational study collecting de-identified clinical information from medical records and follow-up phone calls from many hospitals. It aims to include 5000 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants' mortality rates will be measured at 30 days and 1 year after hospital discharge.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT04682483

Cardiogenic Shock Working Group Registry

Recruiting
Not specifiedAges 18+Observational
Tufts Medical Center
~5,000 participants
Updated 2025-06-06 on ClinicalTrials.gov
What's tested:VasopressorInotropeAcute Mechanical Circulatory Support Devices

At a glance

Recruiting sites
16 of 16 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Rate of Mortality
Measured over 30 days after discharge
+1 more outcome measured
Cardiogenic Shock

NCT04682483

Where you'd take part

This study runs at 16 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Tufts Medical Center

    Boston, Massachusettsstudy coordinator listed

    Recruiting

  • Allegheny General Hospital

    Pittsburgh, Pennsylvaniano site contact published

    Recruiting

  • Baylor Scott & White Advanced Heart Failure Clinic

    Dallas, Texasno site contact published

    Recruiting

  • Beth Israel Deaconess Medical Center

    Boston, Massachusettsno site contact published

    Recruiting

  • Cleveland Clinic Florida

    Weston, Floridano site contact published

    Recruiting

  • Columbia University Irving Medical Center

    New York, New Yorkno site contact published

    Recruiting

  • Hackensack Meridian Health

    Hackensack, New Jerseyno site contact published

    Recruiting

  • Houston Methodist Hospital

    Houston, Texasno site contact published

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

  • Reshad Garan, MD · STUDY_DIRECTOR · Beth Israel Deaconess Medical Center
  • Claudius Mahr, DO · STUDY_DIRECTOR · University of Washington
  • Jaime Hernandez-Montfort, MD · STUDY_DIRECTOR · Cleveland Clinic Foundation-Florida
  • Daniel Burkhoff, MD PhD · STUDY_DIRECTOR · CardioVascular Research Foundation

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Eligibility criteria

Inclusion

Patients must have cardiogenic shock.
Cardiac Index \< 2.2
PAPI \< 1.0
Cardiac Power Output ≤ 0.6
MAP \< 60mmHg or a \>30mmHg drop in MAP from baseline
SBP \< 90mmHg or a \>30mmHg drop in SBP from baseline
Pulse \> 100 2. Require at least one acute mechanical circulatory support device, vasopressor or inotrope to maintain values above the above target.
  • Rate of Mortality30 days after discharge

    Death in subjects during the time frame.

  • Rate of Mortality1 year after discharge

    Death in subjects during the time frame.