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Understanding Primary Sclerosing Cholangitis (PSC)

This observational study aims to better understand Primary Sclerosing Cholangitis (PSC), a rare chronic liver disease affecting the bile ducts. Researchers want to learn how different factors interact to cause PSC. They will collect and analyze various biological information from people with PSC to identify patterns and potential causes. The goal is to gain a deeper understanding of the disease's development and progression. You may be eligible if you are an adult aged 18 to 90 with PSC. The study is currently unclear on its recruitment status.

Study design
This is an observational study with a planned enrollment of 143 participants. It is not testing a specific intervention or drug.
What's involved
You will have a medical history, physical exam, and blood tests. You will provide blood, saliva, urine, and stool samples, and nasal swabs, and complete surveys. You will also have an intravenous (IV) catheter inserted and undergo a colonoscopy.
Compensation
Not stated in the trial record.
Follow-up
The primary goal is measured at the End of Study, but the duration of your participation is not specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT04685200

Unraveling the Mechanisms Underlying Primary Sclerosing Cholangitis Through a Multidisciplinary, Integrative Research Approach

Recruiting
Not specifiedAges 18–90Observational
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
~143 participants
Updated 2026-08-28 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
The ultimate goal of this study is to generate understanding of how factors driving pathogenesis in PSC interact by capturing and integrating collated datasets from across relevant biologic systems and interpreting those in the context of phenot...
Measured over End of Study

Conditions

Primary Sclerosing Cholangitis

Explore related trials

Inflammatory Bowel DiseasePrimary Sclerosing Cholangitis

Where it's being run

1 sites across 1 states
Maryland1

Study leadership

  • Theo Heller, M.D. · PRINCIPAL_INVESTIGATOR · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Who to contact

Alaina K Magnani
[email protected]
(301) 451-6984
Email the study team

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What this trial measures

  • The ultimate goal of this study is to generate understanding of how factors driving pathogenesis in PSC interact by capturing and integrating collated datasets from across relevant biologic systems and interpreting those in the context of phenot...End of Study

    1\. Identification of immune signatures at multiple levels and from different anatomical sites and tissues 2. Characterization of microbiome signatures (taxonomic and functional), as well as identification of specific species. 3. Identification of metabolomic signatures from different anatomical sites and tissues as well as identification of different biomarkers correlating with disease progression. 4. MicroRNA profiling of portal and systemic blood.