This study is looking at how a high-fat drink, specifically 100 ml of heavy cream, affects blood flow in the brain of older adults. Researchers want to understand if carrying a specific gene called APOE E4, which is linked to Alzheimer's disease, changes how your brain responds to fat. You can join if you are 55 or older, and the study aims to include an equal number of APOE E4 carriers and non-carriers, as well as men and post-menopausal women. The main goal is to see the difference in global cerebral blood flow (blood flow in the brain) two hours after drinking the heavy cream. The study is currently unclear on its recruitment status and plans to enroll 90 participants.

Study design

This interventional study plans to enroll 90 older adults, with an equal number of APOE E4 carriers and non-carriers.

What's involved

You will have a screening visit involving a blood draw, an oral triglyceride tolerance test, and a DEXA scan. The study visit includes an MRI to measure brain blood flow before and 2 hours after drinking heavy cream, 6 blood draws, and a 30-minute cognitive test.

Compensation

Not stated in the trial record.

Follow-up

The primary endpoint is measured at 2 hours after the intervention.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.