Compassionate Use of Domperidone for Refractory Gastroparesis

This program is for young people aged 12 to 21 who have severe symptoms from gastroesophageal reflux disease (GERD) or other stomach motility problems, like nausea, vomiting, or severe indigestion. These are people whose conditions haven't improved with standard treatments. The study aims to see if domperidone, taken four times a day, can help reduce the severity of these symptoms. Doctors will adjust the dose of domperidone based on your body weight. The main goal is to see how much your disease severity changes over up to one year. This study plans to include 20 participants, but its current status is unclear.

Study design
This is an interventional study planning to enroll 20 participants aged 12 to 21.
What's involved
You will have a medical history review, physical exam, ECG (a test of your heart's electrical activity), and blood draws before starting. If eligible, you will take domperidone four times daily, and have physical exams, blood draws, and ECGs every two months for the first year.
Compensation
Not stated in the trial record.
Follow-up
You will be followed for changes in disease severity for up to one year.

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NCT04699591

Compassionate Use of Domperidone for Refractory Gastroparesis

Recruiting
NAAges 12–21InterventionalTreatment
Jose Cocjin
~20 participants
Updated 2026-03-24 on ClinicalTrials.gov
What's tested:Domperidone

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in disease severity
Measured over Up to 1 year
GERD
Gastroesophageal Reflux
Gastroparesis
1 sites across 1 states
Missouri1
  • Jose Cocjin, MD · PRINCIPAL_INVESTIGATOR · Children's Mercy Hospital Kansas City

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

increased prolactin levels
extrapyramidal side effects
breast changes
Cardiac arrhythmias including QT prolongation
There is a potential for increased risk of adverse events with the drugs and herbal supplements listed in the addendum (See Addendum on pages 24 and 25)
The coordinator/investigator will have a discussion with the family about the use of any of the medications and herbal supplements listed in the addendum to make sure they understand the increased risk of their use and the need to contact the investigators prior to using any of the listed medications and herbal supplements.
  • Change in disease severityUp to 1 year

    refractory gastroparesis or GERD(Gastroesophageal Reflux Disease)