PyL Imaging for High-Risk and Recurrent Prostate Cancer

This study is looking at a new imaging method called PyL PET/CT for men with prostate cancer. The goal is to see if PyL PET/CT can find cancer spread (metastases) that standard imaging tests might miss. Researchers believe PyL PET/CT could give a clearer picture of where the cancer is. You might be able to join if you are a man aged 18 or older with confirmed prostate cancer and either have high-risk prostate cancer (based on PSA levels, Gleason score, or tumor stage) or your prostate cancer has returned after treatment (biochemical relapse). The study will measure how well PyL PET/CT detects these unsuspected metastases within four weeks.

Study design
This is an interventional study planning to enroll 184 participants. It is designed to assess the clinical value of PyL PET/CT in two groups of prostate cancer patients.
What's involved
You would receive a PyL PET/CT scan. If the scan shows areas of concern not seen on standard imaging, a biopsy might be performed to confirm if it's cancer.
Compensation
Not stated in the trial record.
Follow-up
The primary outcomes, detection of unsuspected metastases, will be measured up to 4 weeks after the scan.

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NCT04700332

PyL in Patients With High Risk and Biochemically Recurrent Prostate Cancer

Recruiting
PHASE2Ages 18+InterventionalDiagnostic
Hoag Memorial Hospital Presbyterian
~184 participants
Updated 2021-07-27 on ClinicalTrials.gov
What's tested:DCFPyL PET/CT

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Detection of unsuspected metastases in high risk prostate cancer
Measured over up to 4 weeks
+1 more outcome measured
Prostate Cancer
1 sites across 1 states
California1
  • Deborah Fridman, PsyD, RN · STUDY_DIRECTOR · Hoag Memorial Hospital Presbyterian

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  • Detection of unsuspected metastases in high risk prostate cancerup to 4 weeks

    Determine the rate of detection of unsuspected metastases in patients with high risk prostate cancer and planned prostatectomy or radiation therapy.

  • Detection of unsuspected metastases in biochemically recurrent prostate cancerup to 4 weeks

    Determine the rate of detection of unsuspected metastases in patients with biochemically recurrent prostate cancer, yet no evidence of disease on CT/bone scan.