Observational Study on Microenvironment and Male Fertility
This study is looking at the relationship between the tiny living organisms (microbiota) in the body and male infertility. Researchers want to understand if certain bacteria in the gut and semen negatively affect fertility. They are also studying how hormone replacement therapy (a treatment for low hormone levels) might be influenced by the gut microbiota in men with infertility and low hormone levels (hypogonadism). You may be able to join if you are an adult man diagnosed with infertility and have not had hormone replacement therapy or used antibiotics in the last six months. The main goal is to understand the types of microbiota present, with results expected after 12 months. The study status is currently unclear.
- Study design
- This is an observational study, meaning researchers will observe and collect information without providing specific treatments. It plans to enroll 150 men.
- What's involved
- Participants will provide semen, blood, and rectal swab samples at different times. The specific schedule for these collections is not detailed.
- Compensation
- Not stated in the trial record.
- Follow-up
- The primary endpoint, characterization of the microbiota, is measured at 12 months, suggesting a follow-up period of at least this duration.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Relationship of the Microenvironment and Male Fertility
At a glance
Conditions
NCT04704141
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
University of Illinois Hospital
Chicago, Illinoisstudy coordinator listed
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- Samuel Ohlander, MD · PRINCIPAL_INVESTIGATOR · University of Illinois at Chicago
Who to contact
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Inclusion
Exclusion
What this trial measures
- Characterization of the Microbiota12 months
16S rRNA sequencing of bacterial DNA found in semen and rectal swab samples will be completed on all samples obtained from participants. This will characterize the microbiota profile of each sample.