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Gender Differences in the Effects of Inhaled THC

This study is looking at how inhaled THC (delta-9-tetrahydrocannabinol) affects men and women differently. Researchers want to understand these differences and why they might occur. You might be able to join if you are between 18 and 55 years old, have used cannabis at least once before, and are in good physical and mental health. You cannot join if you have never used cannabis or are experiencing major stress. The study will measure how rewarding the effects of THC are and how it impacts verbal learning. The study is currently unclear on its recruitment status and plans to enroll about 100 participants.

Study design
This interventional study plans to enroll 100 participants to receive either 4 mg inhaled THC or an inhaled placebo (no active cannabinoids).
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Rewarding effects are measured up to 300 minutes (5 hours) after administration, and verbal learning is measured at baseline and 80 minutes after administration.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT04704271

Gender Related Differences in the Acute Effects of Delta-9-Tetrahydrocannabinol in Healthy Humans: Sub-Study II

Recruiting
PHASE1Ages 18–55InterventionalBasic science
Yale University
~100 participants
Updated 2026-04-29 on ClinicalTrials.gov
What's tested:Inhaled THCPlacebo

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change from Baseline: Rewarding Effects measured by Visual Analog Scale (VAS)
Measured over Changes in "high" assessed over the following timepoints: baseline, +60, +80, +120, +180, +300 minutes after start of oral Dronabinol administration.
+1 more outcome measured

Conditions

Cannabis

Explore related trials

Healthy

Where it's being run

1 sites across 1 states
Connecticut1

Who to contact

Carly Hewes, BS
[email protected]
2039325711 · ext. 7411
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

At least one lifetime exposure to cannabis
Good physical and mental health

Exclusion

Cannabis naïve individuals
Major current or recent stressors

What this trial measures

  • Change from Baseline: Rewarding Effects measured by Visual Analog Scale (VAS)Changes in "high" assessed over the following timepoints: baseline, +60, +80, +120, +180, +300 minutes after start of oral Dronabinol administration.

    Subjective measure of THC induced "high"

  • Change from Baseline: Verbal Learning: Measured by Rey Auditory Verbal Learning Test (RAVLT)Baseline and +80 minutes after start of oral Dronabinol administration.

    Measured as delay recall on the AVLT