The PROGRAM-study: Glioblastoma Resection Techniques
This study is looking at different ways to remove glioblastoma (a type of brain tumor) that is located near important brain areas. Doctors want to see how well three different surgical approaches work: awake mapping (where you are awake during part of the surgery), asleep mapping (where you are asleep, but special tools are used to guide the surgeon), or surgery without mapping. You might be able to join if you are between 18 and 90 years old and have a glioblastoma near areas of the brain that control movement, speech, or vision. The study will measure how well the tumor is removed and if there are any new neurological problems after surgery. The current recruitment status is unclear.
- Study design
- This is an international study involving many centers, planning to include 453 participants. It is an observational study, meaning researchers will watch and record what happens with each surgical approach.
- What's involved
- Not specified in the trial record.
- Compensation
- Not stated in the trial record.
- Follow-up
- You will have follow-up appointments according to standard practice, with neurological health checked at 6 weeks, 3 months, and 6 months after surgery. Tumor removal will be checked within 72 hours of surgery.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
The PROGRAM-study: Awake Mapping Versus Asleep Mapping Versus No Mapping for Glioblastoma Resections
At a glance
Conditions
Where it's being run
8 sites across 6 statesStudy leadership
- Jasper Gerritsen, MD · STUDY_DIRECTOR · Erasmus Medical Center
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
What this trial measures
- Neurological morbidityBetween baseline and 6 weeks/3 months/6 months postoperatively
NIHSS deterioration of 1 point or more as compared to baseline value.
- Extent of resectionAssessed within 72 hours on postoperative MRI scan
Resection percentage as assessed by an independent neuroradiologist on MRI contrast images with volumetric analysis