CPAP Therapy for Obstructive Sleep Apnea and Blood Pressure

This observational study is looking at how CPAP (continuous positive airway pressure) therapy affects blood pressure in people with obstructive sleep apnea (OSA). Researchers want to see if the impact of CPAP on your 24-hour average blood pressure changes depending on your specific sleep apnea symptoms. You might be able to join if you are between 30 and 75 years old, have moderate to severe OSA, and are willing to have your blood pressure monitored at the start of the study and again after 6 months of CPAP use. The study aims to enroll 1739 participants, but its current status is unclear.

Study design
This is a multi-center, observational study comparing people with moderate to severe obstructive sleep apnea who use CPAP therapy to those who do not. It plans to enroll 1739 participants.
What's involved
You would complete blood pressure monitoring at the start and after 6 months. You would also provide blood samples, complete questionnaires, and have an electrocardiogram (ECG) and facial photographs taken. You will also be contacted by phone once a year for ten years.
Compensation
Not stated in the trial record.
Follow-up
Measurements are collected at baseline and 6-month follow-up. Participants will also be contacted by telephone once a year over a ten-year period.

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NCT04712656

Effects of CPAP Therapy on Blood Pressure and Heart Rate Variability in Obstructive Sleep Apnea

Recruiting
Not specifiedAges 30–75Observational
Ohio State University
~1,739 participants
Updated 2025-07-24 on ClinicalTrials.gov
What's tested:CPAP therapy

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
24-hour Mean Blood Pressure
Measured over Measurements will be conducted at baseline (prior to CPAP therapy) and 6-months after initiation of CPAP therapy.
Sleep Apnea, Obstructive
1 sites across 1 states
Ohio1
  • Ulysses Magalang, MD · PRINCIPAL_INVESTIGATOR · Ohio State University

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Eligibility criteria

Inclusion

30 to 75 years of age
Among patients with hypertension, no change in BP medication for at least 3 months.
Willing and able to give informed consent
Willing and able to complete ambulatory blood pressure monitoring at baseline and after 6-months.
Sleep study \[Polysomnography (PSG) or Home Sleep Apnea Study (HSAT) performed based on clinical grounds
4% oxygen desaturation index (ODI4) ≥15 events/hour on clinical sleep study
Planned CPAP treatment by treating provider

Exclusion

Unable to apply BP cuff (e.g. arm circumference \>55 cm, prior breast cancer, structural abnormalities of the arm)
Current use of CPAP or Dental Device for OSA
Category III-IV of heart failure
Presence of Cheyne-Stokes Respiration (CSR) in PSG
Predominantly central sleep apnea (AHI≥15 events/hour)
Pregnancy
History of renal failure, or renal transplant
Self-reported sleep duration less than 5 hours per night on weeknights (work nights)
Other sleep disorders
Use of supplemental oxygen during wakefulness or sleep
Self-reported illicit drug use or marijuana use more than once per week
Unstable medical conditions: uncontrolled angina, uncontrolled hypertension, severe chronic obstructive pulmonary disease, active cancer, or unstable psychiatric disease
Any underlying condition that, in the opinion of the lead investigator, prohibits participation in the study
  • 24-hour Mean Blood PressureMeasurements will be conducted at baseline (prior to CPAP therapy) and 6-months after initiation of CPAP therapy.

    24-hour Mean Blood Pressure obtained from ambulatory blood pressure monitoring (ABPM)