Vitamin C Study for Blood Vessel Health in Obesity and Insulin Resistance
This study is looking into how high blood pressure (hypertension) develops in adults who are obese and have insulin resistance. Researchers want to understand how the blood vessels and the nerves that control them are affected. They are testing whether an infusion of ascorbic acid (Vitamin C) can improve how well your blood vessels work. You might be able to join if you are 35-65 years old, obese (BMI over 30), and willing to stop taking certain supplements before the study. The study will measure the effects of ascorbic acid at 30, 60, and 90 minutes after it's given. The current recruitment status is unclear.
- Study design
- This interventional study plans to enroll 23 participants. It will compare the effects of ascorbic acid solution to a placebo (saline).
- What's involved
- You would need to stop taking vitamin C or E supplements or omega-3 fatty acids starting 2 weeks before the study. You would receive an infusion of either ascorbic acid solution or saline.
- Compensation
- Not stated in the trial record.
- Follow-up
- The main effects of the treatment will be measured at 30, 60, and 90 minutes after the infusion.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Sympathetic-vascular Dysfunction in Obesity and Insulin Resistance (Vitamin C Study)
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Seth Holwerda, PhD · PRINCIPAL_INVESTIGATOR · University of Kansas Medical Center
Who to contact
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What this trial measures
- Efficacy of infusion of ascorbic acid30 minutes
The difference in sympathetic-vascular transduction (mmHg) between ascorbic acid and placebo infusion will be taken as a measure of the modulation of SVT by oxidative stress.
- Efficacy of infusion of ascorbic acid60 minutes
The difference in sympathetic-vascular transduction (mmHg) between ascorbic acid and placebo infusion will be taken as a measure of the modulation of SVT by oxidative stress.
- Efficacy of infusion of ascorbic acid90 minutes
The difference in sympathetic-vascular transduction (mmHg) between ascorbic acid and placebo infusion will be taken as a measure of the modulation of SVT by oxidative stress.
- Efficacy of infusion of ascorbic acid120 minutes
The difference in sympathetic-vascular transduction (mmHg) between ascorbic acid and placebo infusion will be taken as a measure of the modulation of SVT by oxidative stress.