Vitamin C Study for Blood Vessel Health in Obesity and Insulin Resistance

This study is looking into how high blood pressure (hypertension) develops in adults who are obese and have insulin resistance. Researchers want to understand how the blood vessels and the nerves that control them are affected. They are testing whether an infusion of ascorbic acid (Vitamin C) can improve how well your blood vessels work. You might be able to join if you are 35-65 years old, obese (BMI over 30), and willing to stop taking certain supplements before the study. The study will measure the effects of ascorbic acid at 30, 60, and 90 minutes after it's given. The current recruitment status is unclear.

Study design
This interventional study plans to enroll 23 participants. It will compare the effects of ascorbic acid solution to a placebo (saline).
What's involved
You would need to stop taking vitamin C or E supplements or omega-3 fatty acids starting 2 weeks before the study. You would receive an infusion of either ascorbic acid solution or saline.
Compensation
Not stated in the trial record.
Follow-up
The main effects of the treatment will be measured at 30, 60, and 90 minutes after the infusion.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT04715022

Sympathetic-vascular Dysfunction in Obesity and Insulin Resistance (Vitamin C Study)

Recruiting
PHASE1Ages 35–65InterventionalTreatment
University of Kansas Medical Center
~23 participants
Updated 2025-06-08 on ClinicalTrials.gov
What's tested:Ascorbic acid solution (American Regent Laboratories Inc.)Saline

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Efficacy of infusion of ascorbic acid
Measured over 30 minutes
+3 more outcomes measured
Hypertension
Cardiovascular Diseases
1 sites across 1 states
Kansas1
  • Seth Holwerda, PhD · PRINCIPAL_INVESTIGATOR · University of Kansas Medical Center

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  • Efficacy of infusion of ascorbic acid30 minutes

    The difference in sympathetic-vascular transduction (mmHg) between ascorbic acid and placebo infusion will be taken as a measure of the modulation of SVT by oxidative stress.

  • Efficacy of infusion of ascorbic acid60 minutes

    The difference in sympathetic-vascular transduction (mmHg) between ascorbic acid and placebo infusion will be taken as a measure of the modulation of SVT by oxidative stress.

  • Efficacy of infusion of ascorbic acid90 minutes

    The difference in sympathetic-vascular transduction (mmHg) between ascorbic acid and placebo infusion will be taken as a measure of the modulation of SVT by oxidative stress.

  • Efficacy of infusion of ascorbic acid120 minutes

    The difference in sympathetic-vascular transduction (mmHg) between ascorbic acid and placebo infusion will be taken as a measure of the modulation of SVT by oxidative stress.