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IMPACT Frailty: Understanding Frailty and Sarcopenia in Critically Ill Patients

This study, called IMPACT Frailty, is looking at frailty (a decline in physical and mental reserves that makes people more vulnerable to stress) and sarcopenia (muscle wasting) in critically ill patients. Researchers want to understand what factors can be changed to help reduce frailty. They will collect 2D ultrasound images of muscles and analyze blood for inflammatory and nutritional biomarkers. Patients or their caregivers will also complete a Frailty Index Questionnaire. The study aims to see how these factors relate to how long patients stay in the ICU and hospital, and where they go after discharge. You might be able to join if you are an adult admitted to the Surgical, Cardiothoracic, or Neuro ICU and expect to stay longer than 24 hours.

Study design
This is an observational study involving 250 participants. It is designed to track sarcopenia in critically ill patients.
What's involved
You would have 2D ultrasound images taken and blood samples collected for biomarker analysis. You or your surrogate would also complete a Frailty Index Questionnaire.
Compensation
Not stated in the trial record.
Follow-up
Patients will be followed from enrollment until hospital discharge, which is approximately 2 weeks to 2 months.

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NCT04717869

Identifying Modifiable PAtient Centered Therapeutics (IMPACT) Frailty

Recruiting
Not specifiedAges 18+Observational
University of California, Los Angeles
~250 participants
Updated 2026-01-30 on ClinicalTrials.gov
What's tested:UltrasoundBiomarker AnalysisFrailty Index

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Discharge Disposition
Measured over Patients will be followed from enrollment to hospital discharge. Approximately 2 weeks to 2 months
+2 more outcomes measured

Conditions

Frailty
Sarcopenia

Explore related trials

FrailtySarcopenia

Where it's being run

1 sites across 1 states
California1

Study leadership

  • Cecilia Canales, MD, MPH · PRINCIPAL_INVESTIGATOR · UCLA Department of Anesthesiology and Perioperative Medicine

Who to contact

Jennifer Scovotti, MA
[email protected]
3102064484
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Adult patients admitted to the Surgical, Cardiothoracic or Neuro ICU
ICU stay longer than 24 hours

Exclusion

Patients with muscular or mitochondrial diseases affecting muscle quality or mass
Preexisting paralysis
Absence of lower limbs
Ongoing discussions about goals of care
Transfers from a skilled nursing facility
Children under the age of 18

What this trial measures

  • Discharge DispositionPatients will be followed from enrollment to hospital discharge. Approximately 2 weeks to 2 months

    Disposition of patient at time of hospital discharge, home, rehabilitation or skilled nursing facility, in hospital death

  • Length of ICU stayPatients will be followed from enrollment to ICU transfer. Approximately 2 weeks to 2 months

    Length of time patient is admitted to ICU until transfer out of the ICU

  • Length of Hospital stayPatients will be followed from enrollment until discharge from the hospital. Approximately 2 weeks to 2 months

    Length of time patient is admitted to the hospital including length of time patient spends in the ICU until discharge or death