Personalized Responses to Dietary Composition Trial 3 (PREDICT 3)

This study, called PREDICT 3, is looking at how different foods affect individuals. Researchers want to improve computer models that predict how your body responds to food, helping to create personalized diet advice. You would participate in a dietary intervention using standardized meals, where your body's response after eating (postprandial response) is measured. This information, along with details about your metabolism, body measurements, sleep, and exercise, will be used to understand how your body reacts to various foods. The study aims to understand how factors like exercise and sleep influence these responses. To join, you must be at least 18 years old, have a BMI of 16.5 or higher, live in the continental US (excluding New York), and be enrolled in the commercial ZOE testing program. The study is currently unclear on its recruitment status.

Study design
This is a single-arm study, meaning all participants receive the same intervention. It plans to enroll 250,000 participants.
What's involved
You will participate for 6-14 days. You will wear a glucose monitor and eat two standardized meals provided by the study team on up to 6 days, recording any leftover food using a digital app.
Compensation
Not stated in the trial record.
Follow-up
Your glucose levels will be measured for 6-14 days, and gut microbiome species richness and blood lipids will be measured at 1 day.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT04735835

Personalized Responses to Dietary Composition Trial 3

Recruiting
NAAges 18+InterventionalPrevention
Zoe Global Limited
~250,000 participants
Updated 2025-04-16 on ClinicalTrials.gov
What's tested:Dietary Intervention

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Glucose
Measured over 6-14 days
+4 more outcomes measured
Diabetes
Heart Diseases
Diet Habit
Diet Modification
Healthy
Obesity
Metabolism
Microbial Colonization
2 sites across 2 states
Massachusetts1
United Kingdom1
  • Tim Spector, PhD · PRINCIPAL_INVESTIGATOR · Zoe Global Limited

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Eligibility criteria

Inclusion

Enrolled in the commercial ZOE testing program
Any sex
Minimum 18 years of age (minimum 19 years of age in Alabama and Nebraska due to state laws)
Body mass index (BMI) of greater than or equal to 16.5 kg/m2.
Living in the continental US states, other than in New York (excluded from the ZOE testing product also as they are unable to access the dried blood spot service provided by Quest), or living in the UK
Able and willing to comply with the study protocol and provide informed consent.
Under care for chronic medical conditions (including eating disorders, type 1 diabetes, type 2 diabetes), and confirm they have checked with their primary care physician that this study is safe for them (US cohort only)

Exclusion

Cannot safely eat the pre-made test meals which contain standard US ingredients, e.g. due to allergy or recent gastrointestinal surgery, or are unwilling to consume these foods.
Are pregnant.
Have had a heart attack (myocardial infarction), stroke/transient ischemic attack (TIA), or major surgery in the last two months.
Are unable to read and write in English, as the ZOE app is only available in English.
  • Glucose6-14 days

    Measurement of blood glucose by continuous glucose monitor (mmol/L)

  • Gut microbiome species richness1 day

    Species count in fecal sample (as part of ZOE testing program)

  • Blood Lipids1 day

    Measurement of baseline and 6-h post-prandial triglycerides (mmol/L) by dried blood sample (as part of ZOE testing program)

  • Hunger and appetite assessment6-14 days

    Self-reported in-app question on energy levels (categorical) (as part of ZOE testing program)

  • Glucose and HbA1c2 days

    Measurement of baseline glucose (mmol/L) and HbA1c (%) by dried blood sample (as part of ZOE testing program)