Back to search results

Alkaline Glycine for Airway pH Measurement in Airway Disease

This study is looking for people aged 18-60, with or without airway disease, to help researchers find a new, less invasive way to measure airway pH. Airway pH is how acidic or alkaline your airways are, and imbalances can cause breathing problems. Currently, measuring airway pH involves an invasive procedure. This study will have you inhale alkaline glycine, a medication, through a nebulizer. Researchers will then measure your exhaled nitric oxide levels and exhaled breath condensate pH to see if these non-invasive methods can accurately show your airway pH. The study aims to find better ways to understand and manage airway conditions. The current status of this study is unclear.

Study design
This is an interventional study with a planned enrollment of 150 participants. It is not specified if the study is randomized or blinded.
What's involved
You would have a single study visit lasting less than two hours. During this visit, you would inhale alkaline glycine and have your exhaled breath measured.
Compensation
Not stated in the trial record.
Follow-up
Measurements are taken during a single visit, lasting less than two hours. There is no specified follow-up period after this visit.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT04738422

Determining Airway pH by Compartmental Exhaled Nitric Oxide Levels During Alkaline Buffer Challenge

Enrolling by Invitation
PHASE2Ages 18–60InterventionalDiagnostic
Indiana University
~150 participants
Updated 2025-12-09 on ClinicalTrials.gov
What's tested:Alkaline glycine

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Compartmental FeNO
Measured over Study is a single visit, lasting less than two hours
+2 more outcomes measured

Conditions

Airway Disease

Explore related trials

Airway DiseaseAsthmaChronic Lung DisorderChronic Obstructive Pulmonary DiseaseHealthy VolunteersRespiratory System Disorder

Where it's being run

1 sites across 1 states
Indiana1

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

• Study sample will consist of individuals aged 18-60 with a diagnosis of acute or chronic respiratory disorders or normal subjects with no pulmonary disease.

Exclusion

• Subjects that are mechanically ventilated.
Subjects that are unable or unwilling to cooperate with specimen collection.
Subjects with diagnosis of any medical condition that in the investigator's opinion would make them unsuitable for study participation.
Subjects who experienced a pulmonary exacerbation within the 4 weeks prior to visit.
Subjects requiring continuous oxygen therapy.

What this trial measures

  • Compartmental FeNOStudy is a single visit, lasting less than two hours

    Measuring compartmental FeNO before inhaled alkaline glycine and after inhaled alkaline glycine

  • Calculated compartmental airway pHStudy is a single visit, lasting less than two hours

    Calculating compartmental FeNO before inhaled alkaline glycine and after inhaled alkaline glycine

  • Exhaled Breath Condensate (EBC) pHStudy is a single visit, lasting less than two hours

    Measuring the pH of EBC before and after inhaled alkaline glycine