HIV Prevention for People Who Inject Drugs: CoMPASS Study

This study is testing a program called CoMPASS (Contingency Management with stepped care to PrEP Adherence and Support Services) to help prevent HIV. CoMPASS combines support for taking PrEP (pre-exposure prophylaxis, a medicine to prevent HIV) with services for opioid use disorder. You might be able to join if you are 18 or older, have injected drugs in your lifetime, and meet criteria for PrEP. The study wants to see if CoMPASS helps people consistently take PrEP for 24 weeks. The study is currently recruiting about 526 participants, but its exact status is unclear.

Study design
This is a multi-site randomized clinical trial, meaning participants are randomly assigned to receive CoMPASS or usual care. The study plans to enroll 526 participants.
What's involved
Participants in the CoMPASS group will receive 9 contingency management sessions. If PrEP adherence isn't met by week 12, additional support services will be provided. The intervention lasts 24 weeks.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 12 months after the 24-week intervention period.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT04738825

Promoting HIV Risk Reduction Among People Who Inject Drugs: A Stepped Care Approach Using Contingency Management With PrEP Adherence and Support Services

Active, Not Recruiting
NAAges 18+InterventionalTreatment
Yale University
~526 participants
Updated 2026-08-14 on ClinicalTrials.gov
What's tested:Contingency Management with stepped care to PrEP adherence and support services (CoMPASS)

At a glance

Recruiting sites
0 of 6 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Sustained PrEP adherence
Measured over 24 weeks
Opioid-use Disorder
HIV Prevention Program
6 sites across 2 states
Connecticut5
Massachusetts1
  • E. Jennifer Edelman, MD, MHS · PRINCIPAL_INVESTIGATOR · Yale University

This trial hasn't published a contact. View it on ClinicalTrials.gov

  • Sustained PrEP adherence24 weeks

    Determined by tenofovir-diphosphate levels by dried blood spot testing or objective confirmation.