Food and Circadian Timing Study

This study aims to understand how different diets affect your body's internal clock, called the circadian rhythm. Researchers will compare a High-Fat Diet and a Low-Fat Diet to see how each impacts the speed at which your body adjusts to a new schedule. They hope to learn if diet plays a role in how well your body's clock stays in sync with the 24-hour day. You may be able to join if you are a healthy, lean man or woman between 18 and 40 years old. The study is looking to enroll 14 participants, but its current recruitment status is unclear.

Study design
This is a randomized crossover study involving 14 participants. This means participants will receive both the High-Fat Diet and the Low-Fat Diet at different times.
What's involved
You would participate for a total of 46 days, including 28 days as an outpatient and two separate 9-day stays in a clinic.
Compensation
Not stated in the trial record.
Follow-up
The primary outcome, change in speed of entrainment, is measured over 18 days.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT04743271

Food and Circadian Timing

Recruiting
NAAges 18–40Interventional
Oregon Health and Science University
~14 participants
Updated 2025-11-10 on ClinicalTrials.gov
What's tested:High-Fat DietLow-Fat Diet

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in Speed of entrainment
Measured over Over 18 days
Diet, High-Fat
Circadian Rhythm
1 sites across 1 states
Oregon1
  • Andrew McHill, PhD · PRINCIPAL_INVESTIGATOR · Oregon Health and Science University

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Healthy, lean men and women

Exclusion

Major dietary restrictions (such as entirely dairy-free and/or meat-free diets)
A body mass index (BMI) of 18.5\< \[BMI\] \< 24.9 kg/m\^2 and a waist circumference \<94/80cm
Currently psychiatrically/psychologically unsuitable for participation
Drug/alcohol use, including smoking
Medication/drug use, including prescribed and over-the-counter medications
History of working irregular day and night hours, regular night work, or rotating shift work for the 1 year prior to the study.
Traveled across more than 1 time zone during the 3 months prior to the study
Currently consuming a habitual high-fat diet
Chronobiologic and sleep disorders
Diseases of the Cardiovascular System
Metabolic Syndrome; Two or more of these factors will be excluded from the study:
Pre-Diabetes/Diabetes
Hypertension
Disorders of the Respiratory System
Disorders of the Kidney and Urinary Tract
Infectious Diseases
Disorders of the Gastrointestinal System
Disorders of the Immune System
Disorders of the Hematopoietic System
Neoplastic Diseases
Endocrine and Metabolic Diseases
Neurologic Disorders
Subjects must not be currently participating in another research study that would influence their safe participation in our study
  • Change in Speed of entrainmentOver 18 days

    Entrainment will be determined as a stable phase angle between sleep and both melatonin onset. Blood and/or saliva will be assayed for melatonin using standardized assays. Melatonin onset will be calculated using the linear interpolated time at which melatonin levels reach 25% of a fitted peak-to-trough amplitude. This will be analyzed using phase angle between sleep and melatonin onset.