This study is looking at whether antibiotics are truly needed before an OnabotulinumtoxinA (Botox) injection for overactive bladder (OAB). OnabotulinumtoxinA is an FDA-approved treatment for OAB when other treatments haven't worked. Currently, a single dose of antibiotics is often given before the injection to prevent urinary tract infections (UTIs), which can be a side effect. This study will compare giving no antibiotics to giving a single dose of antibiotics before the OnabotulinumtoxinA injection. You may be able to join if you are at least 18 years old, have OAB that hasn't improved with other treatments, and do not have a UTI at the time of injection. The study will measure how many people get a UTI within 14 days after the injection. The current recruitment status is unclear, and the study plans to enroll 200 participants.

Study design

This is an interventional study comparing two groups: one receiving no antibiotics and one receiving prophylactic antibiotics before OnabotulinumtoxinA injection. It plans to enroll 200 participants.

What's involved

You would receive an OnabotulinumtoxinA injection into your bladder using a cystoscope (a thin, flexible tube with a camera). You would either receive a single dose of antibiotics or no antibiotics before this procedure.

Compensation

Not stated in the trial record.

Follow-up

The study will track whether you develop a symptomatic urinary tract infection for 14 days after the injection.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.