Observational Study on Metals and Pulmonary Hypertension

This observational study is looking at the levels of different metals, including heavy metals like cadmium and lead, and essential metals like iron and zinc, in people with pulmonary arterial hypertension (PAH) and healthy volunteers. Researchers want to understand if imbalances in these metal levels contribute to PAH and its progression. They will measure 31 different metal levels in blood and urine samples. The study aims to enroll 110 participants, including 50 PAH patients and 10 healthy volunteers who are similar in age and gender. The study is currently recruiting participants.

Study design
This is an observational study planning to enroll 110 participants, including 50 PAH patients and 10 healthy controls.
What's involved
If you have PAH, you will have blood and urine samples taken at your regular clinic visits, which occur at least every 6 months. Healthy volunteers will also provide blood and urine samples.
Compensation
Not stated in the trial record.
Follow-up
Metal levels will be measured at up to 12 months.

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NCT04756076

Study Roles of Heavy Metals and Essential Metal Dyshomeostasis in Pulmonary Arterial Hypertension Patients

Recruiting
Not specifiedAges 18+Observational
Jiapeng Huang
~110 participants
Updated 2025-05-30 on ClinicalTrials.gov
What's tested:Metal level measurements

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Metal levels in control and pulmonary hypertension groups
Measured over up to 12 months
Pulmonary Hypertension
Metal Poison
1 sites across 1 states
Kentucky1

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Eligibility criteria

Inclusion

All patients with the diagnosis of pulmonary hypertension
Agree to the study protocol
Healthy volunteers
Age, gender matched controls

Exclusion

Younger than 18 years
Refusal to participate
  • Metal levels in control and pulmonary hypertension groupsup to 12 months

    Metal levels in control and pulmonary hypertension groups