Diuretic Tuner for Swelling in Kidney Disease

This study is testing a mobile phone app called Diuretic Tuner. This app helps people with kidney problems manage swelling (edema or hypervolemia) by guiding them on how to adjust their diuretic medication doses each day. The study wants to see how well the app helps you reach and maintain your ideal body weight. To join, you must be 18 or older and have significant protein in your urine (nephrotic range proteinuria) or advanced chronic kidney disease (stages 4 or 5). The study is currently unclear on its recruitment status, but plans to enroll 30 participants.

Study design
This is a non-randomized study with 30 participants, meaning everyone will use the Diuretic Tuner app. It's an early-stage study to check if the app is safe and works as intended.
What's involved
You will have a 2-hour visit to learn how to use the app. You'll need to check your blood pressure and weight daily, entering this information into the app, and follow its daily medication instructions. You will also have blood tests at 2 weeks, 90 days, and potentially up to four other times.
Compensation
Not stated in the trial record.
Follow-up
The main outcomes are measured at 90 days, focusing on your weight management during that period.

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NCT04759274

Diuretic Tuner Clinical Decision Support

Recruiting
NAAges 18+InterventionalTreatment
University of Texas Southwestern Medical Center
~30 participants
Updated 2025-09-16 on ClinicalTrials.gov
What's tested:Diuretic Tuner

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Mean time to the attainment of dry weight
Measured over 90 days
+1 more outcome measured
Edema
Hypervolemia
Chronic Kidney Diseases
Nephrotic Syndrome
1 sites across 1 states
Texas1

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Eligibility criteria

Inclusion

The presence of nephrotic range proteinuria (\> 3 g/d proteinuria by 24hr urine protein, 24hr urine albumin, spot urine protein/creatinine ratio, or spot urine albumin/creatinine ratio) or stage 4 or 5 chronic kidney disease (estimated glomerular filtration rate \< 30 mL/min/1.73 m2 by Modification of Diet in Renal Disease equation) PLUS
Clinical signs of hypervolemia present (lower extremity edema, ascites, or pleural effusions) with an estimated dry weight (defined as edema-free weight without orthostatic hypotension) 5 lbs less than enrollment body weight

Exclusion

Weight \< 100 lbs or \> 300 lbs.
Autonomic insufficiency resulting in orthostatic hypotension at screening
Hypokalemia at enrollment (defined as serum potassium \< 3.5 mmol/L)
Moderate to severe hyponatremia at enrollment (defined as serum sodium \< 130 mmol/L)
Serum creatinine \> 6 mg/dL or \> 1.5 times baseline
Patients who are unable or unwilling to measure their home blood pressures and weights
Patients without a working phone number and smart phone device
Expectation that the patient will require dialysis initiation within \< 3 months
Expected lifespan of \< 6 months
The presence of a medical condition that would interfere with effectively using the Diuretic Tuner (dementia, illiteracy, or blindness)
Pregnant patients
Prisoners
  • Mean time to the attainment of dry weight90 days

    Mean time in days to the attainment of the provider-specified estimated dry weight

  • 90 day weight variability90 days

    90 day weight variability around the target dry weight, as assessed by standard deviation