Inspiratory Muscle Training After Lung Transplant

This study is looking at how training your breathing muscles (inspiratory muscles) affects your ability to exercise, your quality of life, and your health after a lung transplant. Researchers are testing a device called POWERBreathe Plus® along with standard cardiopulmonary rehabilitation. They want to see if this training can improve your maximal inspiratory mouth pressure (MIP), which is a measure of how strong your breathing muscles are, after 12 weeks. You may be able to join if you are an adult who has had a single or double lung transplant at Mayo Clinic Florida. The study aims to enroll 30 participants, but its current recruitment status is unclear.

Study design
This interventional study plans to enroll 30 adult participants. The study design is not specified as randomized or blinded.
What's involved
You would undergo assessments of your lung function, breathing muscle strength, and diaphragm. You would also complete a cardiopulmonary exercise test, a 6-minute walk test, and an inspiratory muscle endurance test.
Compensation
Not stated in the trial record.
Follow-up
Your maximal inspiratory mouth pressure will be measured at 12 weeks after starting the intervention.

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NCT04783155

Effect of Inspiratory Muscle Training on Physiological Function and Clinical Outcomes After Lung Transplant

Recruiting
NAAges 18+InterventionalSupportive care
Mayo Clinic
~30 participants
Updated 2026-01-06 on ClinicalTrials.gov
What's tested:POWERBreathe Plus®Cardiopulmonary rehabilitation post lung transplant

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Maximal inspiratory mouth pressure (MIP) measured in cmH2O
Measured over 12 weeks
Post-Lung Transplantation Bronchiectasis
1 sites across 1 states
Florida1
  • Bryan Taylor, PhD · PRINCIPAL_INVESTIGATOR · Mayo Clinic

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Eligibility criteria

Exclusion

Patients who do not survive the intra-operative period during the transplant surgery.
Patients undergoing retransplantation.
Patients undergoing multiorgan transplantation.
Patients who are not willing to or who are unable to give written informed consent.
  • Maximal inspiratory mouth pressure (MIP) measured in cmH2O12 weeks

    The maximal strength generating capacity of the inspiratory muscles.