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Evaluating PEG Fusion for Peripheral Nerve Injuries

This study is looking at a new way to help nerves heal after an injury called PEG fusion. It uses a substance called polyethylene glycol (PEG) with other liquids during nerve repair surgery. The goal is to help the ends of cut nerves fuse back together. You might be able to join if you are between 18 and 80 years old and have had a complete peripheral nerve injury (damage to nerves outside the brain and spinal cord) in your arm within 48 hours. The study wants to see if PEG fusion is safe and helps people recover movement and feeling faster than standard surgery. Researchers will compare PEG fusion to conventional nerve reconstruction in 40 patients.

Study design
This study will involve 40 participants who will be randomly assigned to receive either PEG fusion or conventional nerve reconstruction.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be monitored for complications for the first 30 days and for up to 2 years to track their recovery.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT04789044

Evaluating the Safety and Efficacy of Polyethylene Glycol (PEG) Mediated Fusion (PEG Fusion)

Active, Not Recruiting
PHASE2Ages 18–80InterventionalTreatment
Major Extremity Trauma Research Consortium
~40 participants
Updated 2026-09-10 on ClinicalTrials.gov
What's tested:NTX-001

At a glance

Recruiting sites
0 of 7 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Complications or problems that occur with in the first 30 days.
Measured over Up to 2 years

Conditions

Peripheral Nerve Injuries

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Peripheral Nerve Injury

NCT04789044

Where you'd take part

This study runs at 7 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Cooper Health

    Camden, New Jerseyno site contact published

  • Johns Hopkins University School of Medicine

    Baltimore, Marylandno site contact published

  • OrthoCarolina

    Charlotte, North Carolinano site contact published

  • San Antonio Military Medical Center (SAMMC)

    San Antonio, Texasno site contact published

  • University of Maryland Medical Center Shock Trauma Center

    Baltimore, Marylandno site contact published

  • Virginia Commonwealth University Medical Center

    Richmond, Virginiano site contact published

  • Wellspan Health

    York, Pennsylvaniano site contact published

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Ala Elhelali, PhD · PRINCIPAL_INVESTIGATOR · Johns Hopkins University

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

What this trial measures

  • Complications or problems that occur with in the first 30 days.Up to 2 years

    Complications or problems include surgical site infections, wound dehiscence/breakdown, exposure of nerves and/or their repairs and reconstructions, breakdown of nerve repair or reconstruction, seroma/hematoma requiring an additional procedure to treat, and any other local wound complications related to the zone of nerve injury that require an additional surgical procedure