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Cardiovascular Exercise for Type 2 Diabetes and Obesity

This study is looking at how cardiovascular exercise affects people with Type 2 Diabetes, or who are overweight or obese. Researchers want to understand if regular exercise can improve how your body uses insulin (insulin sensitivity) and how well your heart and muscles work. You might be able to join if you are 30-55 years old, sedentary (exercise less than 1 hour per week), and have a BMI between 25-40. The study will measure changes in your fitness level (peak oxygen consumption, or VO2) and insulin sensitivity over about 4 months. The current recruitment status is unclear.

Study design
This is an interventional study planning to enroll 150 participants. It is not specified if it is randomized or blinded.
What's involved
Participants will engage in cardiovascular exercise three times a week for 50 minutes per session, for a total of 15 weeks.
Compensation
Not stated in the trial record.
Follow-up
The primary outcomes will be measured through study completion, which is approximately 4 months.

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NCT04791371

Role of Microvascular Insulin Resistance and Cardiorespiratory Fitness Diabetes

Recruiting
NAAges 30–55InterventionalTreatment
University of Colorado, Denver
~150 participants
Updated 2026-03-23 on ClinicalTrials.gov
What's tested:Cardiovascular exercise

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in peak oxygen consumption (VO2)
Measured over Through study completion, approximately 4 months
+1 more outcome measured

Conditions

Type 2 Diabetes
Overweight and Obesity

Explore related trials

ObesityType 2 Diabetes Mellitus

Where it's being run

2 sites across 2 states
Colorado1
Virginia1

Who to contact

Benjamin Juckett, MS
[email protected]
303-724-1338
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Sedentary (defined as less than 1 hour per week of physical activity)
BMI: 25-40
Men and women with and without type 2 diabetes

Exclusion

Documented cardiovascular disease
Uncontrolled hypertension: disease systolic blood pressure (SBP) \> 150, diastolic blood pressure (DBP)\> 110
Obstructive pulmonary disease or asthma
Peripheral neuropathy
Physical impairment that would limit exercise ability
Subjects taking beta blockers, calcium channel blockers, insulin, or Thiazolidinediones (TZD)
Current or past smoking within the last 1 years
Current tobacco use
Anemia
Control HbA1c \> 5.7, T2DM HbA1c \> 9
Pregnant, nursing or hormonal therapy (other than contraceptives)
Peri or post-menopausal women
Type 1 diabetes
Hepatic or renal disease.

What this trial measures

  • Change in peak oxygen consumption (VO2)Through study completion, approximately 4 months

    Subjects' peak oxygen consumption will be tested on a stationary bike before and after 15 weeks of exercise

  • Change in insulin sensitivityThrough study completion, approximately 4 months

    The investigators will evaluate the changes in insulin sensitivity utilizing a euglycemic insulin clamp