This study is looking at how often a specific gene change, called a BAP1 gene mutation, appears in cancer patients and what types of cancers are linked to it. Researchers want to understand the full range of cancers (clinical phenotypes) that occur in people with this inherited condition, including uveal melanoma (a type of eye cancer), cutaneous melanoma (skin cancer), kidney cancer (renal cell carcinoma), and mesothelioma (a cancer affecting the lining of organs). This research doesn't involve any specific treatments or interventions. You might be able to join if you have a personal history of a BAP1-related cancer and a family history of at least two close relatives with similar cancers. The goal is to better understand this syndrome to help develop new ways to screen for, prevent, and treat these cancers in the future.

Study design

This is an observational study, meaning researchers will gather information without giving any specific treatments. It aims to include 500 participants.

What's involved

Not specified in the trial record.

Compensation

Not stated in the trial record.

Follow-up

Researchers will measure the prevalence of BAP1 variants and clinical phenotypes in family members over 5 years.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.