COCOA-PAD II Trial for Peripheral Artery Disease
This study is looking at whether cocoa flavanols can help people aged 55 and older with Peripheral Artery Disease (PAD). PAD is a condition where narrowed arteries reduce blood flow to your limbs. Participants will take two capsules daily of either cocoa flavanols (about 500 mg) or a placebo (an inactive capsule that looks the same) for six months. The main goal is to see if those taking cocoa flavanols can walk further in six minutes compared to those taking the placebo. We are looking for 190 participants, and the current status of the study is unclear.
- Study design
- This is an interventional study that will randomly assign 190 participants with PAD to one of two groups: cocoa flavanols or placebo.
- What's involved
- Participants will take two capsules daily for six months. The primary measurement will be a six-minute walk test at the beginning and end of the study.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed for six months, with the primary outcome measured at the six-month mark.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
The COCOA-PAD II Trial
At a glance
Conditions
Where it's being run
3 sites across 2 statesStudy leadership
- Mary McDermott, MD · PRINCIPAL_INVESTIGATOR · Northwestern University
Who to contact
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What this trial measures
- Six-month change in six-minute walk distanceBaseline to six-month follow-up
Change in six-minute walk distance at six-month follow-up will be compared between those randomized to cocoa flavanols vs. those randomized to placebo.