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Computerized Tests for Cognitive Decline in Alzheimer's Disease

This study is looking at how healthy people of different ages perform on a collection of computerized cognitive (thinking and memory) tests called the California Cognitive Assessment Battery (CCAB). These tests are given on a tablet at home or in a lab. The main goal is to collect information on how people's scores change over time as they age, which could help in the future to find people at risk for age-related cognitive decline (problems with thinking, memory, and judgment). We are looking for 2000 participants aged 18 to 89 who can use a computer mouse and touch screen, and speak English or Spanish as their primary language. People with a history of psychiatric disorders, stroke, substance abuse, or certain medical conditions cannot join. The current status of this study is unclear.

Study design
This is an interventional study with a planned enrollment of 2000 participants. It is not specified if it is randomized or blinded.
What's involved
You would take computerized cognitive tests for three days at the start, and then every six months for up to three years, depending on the group you are in.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed with longitudinal testing at six-month intervals for up to three years.

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NCT04800588

Computerized Tests of Cognitive Decline in Presymptomatic Alzheimer's Disease

Recruiting
NAAges 18–89InterventionalDiagnostic
Neurobehavioral Systems, Inc.
~2,000 participants
Updated 2025-05-22 on ClinicalTrials.gov
What's tested:California Cognitive Assessment Battery

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Longitudinal normative data collection from healthy participants
Measured over Longitudinal testing at six-month intervals

Conditions

Alzheimer Disease
Cognitive Decline
Aging

Explore related trials

Alzheimer's DiseaseCognitive Dysfunction

Where it's being run

1 sites across 1 states
California1

Who to contact

Kathleen Hall, PhD
[email protected]
510-214-3176
Email the study team

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Eligibility criteria

Inclusion

Must be able to use computer mouse and touch screen
Must speak English as a primary language
Must speak Spanish as a primary language (for Latino participants completing our Spanish translation)

Exclusion

History of psychiatric disorder
History of stroke or transient ischemic attack
History of substance abuse
History of medical or sensory disorders that are incompatible with effective testing
History of traumatic brain injury with hospitalization and extended loss of consciousness
History of epilepsy
History of depression or anxiety

What this trial measures

  • Longitudinal normative data collection from healthy participantsLongitudinal testing at six-month intervals

    Multiple behavioral outcome measures will be obtained from each cognitive test including measures of response time (in milliseconds) and accuracy (in percent correct). Recordings of subject's verbal responses will also be analyzed phonologically and automatically transcribed to permit the lexical, syntactic, and semantic analysis of speech output. Questionnaire data will be used to identify factors that may influence performance on the cognitive tests. The primary outcome measures are the scores obtained during enrollment testing that predict a decline in longitudinal performance.