Observational Study on Periodontal Inflammation and Wound Healing

This observational study is looking at how inflammation in your mouth (periodontal inflammation) affects how well wounds heal after a tooth extraction. Researchers want to understand the immune response during this healing process. You may be able to join if you are between 21 and 70 years old and need to have a back tooth (molar or premolar) extracted that cannot be saved. You cannot have any systemic diseases that affect inflammation. The study will measure inflammatory cells at 3 months after the extraction to see how they relate to healing. The current status of this study is unclear, and it plans to enroll 25 participants.

Study design
This is an observational study involving 25 healthy adult participants. It is not specified if it is randomized or blinded.
What's involved
You would have a tooth extraction, and small tissue samples (biopsies) would be taken during the extraction and at a 2-week follow-up visit. You would also have clinical measurements and X-rays taken before the extraction, at 2 weeks, and at 3 months.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 3 months after the tooth extraction.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT04805320

Association of Periodontal Inflammation on Immune Response in Wound Healing

Recruiting
Not specifiedAges 21–70Observational
University of Nebraska
~25 participants
Updated 2025-12-10 on ClinicalTrials.gov
What's tested:Dental Extraction

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Inflammatory cells
Measured over 3 months
Inflammation of Mouth
1 sites across 1 states
Nebraska1
  • Joseph B Bavitz, DMD · STUDY_CHAIR · University of Nebraska, College of Dentistry

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

non-restorable posterior tooth (molar/premolar) in need of extraction

Exclusion

systemic disease that effects inflammation
  • Inflammatory cells3 months

    Number of inflammatory cells present