Observational Study of Hearing Instability Disorders

This study aims to better understand hearing instability disorders like Meniere's Disease, Enlarged Vestibular Aqueduct Syndrome, and Autoimmune Inner Ear Disease. Researchers want to identify specific markers (biomarkers) in your body and new ways to measure these conditions to find better treatments. You might be eligible if you are an adult between 18 and 80 years old with symptoms of hearing instability. The study will look at your hearing over time, along with information from specialized MRI scans and blood tests. The main goal is to gather detailed information about these conditions to help categorize them better.

Study design
This is an observational study planning to enroll 210 participants. It is not testing a specific intervention but rather collecting information about your condition.
What's involved
You will have a medical and hearing history taken, a physical exam, and blood drawn. Your hearing will be evaluated at several time points over 450 days.
Compensation
Not stated in the trial record.
Follow-up
Your phenomic features (characteristics of your condition) will be measured at approximately 90, 180, 270, 360, and 450 days.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT04806282

Deep Phenotyping of Hearing Instability Disorders: Cohort Establishment, Biomarker Identification, Development of Novel Phenotyping Measures, and Discovery of Therapeutic Targets

Recruiting
Not specifiedAges 18–80Observational
National Institute on Deafness and Other Communication Disorders (NIDCD)
~210 participants
Updated 2026-06-29 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Phenomic features
Measured over Day 90, 180, 270, 360, and 450, respectively +/- 14 days
Meniere's Disease
Enlarged Vestibular Aqueduct Syndrome
Autoimmune Inner Ear Disease
1 sites across 1 states
Maryland1
  • Michael Hoa, M.D. · PRINCIPAL_INVESTIGATOR · National Institute on Deafness and Other Communication Disorders (NIDCD)

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  • Phenomic featuresDay 90, 180, 270, 360, and 450, respectively +/- 14 days

    To identify phenotype features associated with hearing fluctuation