This study is looking at how exercise affects fat tissue in people with obesity and metabolic conditions. Researchers want to understand how exercise improves health, especially in fat tissue, which could lead to new ways to prevent and treat insulin resistance (when your body doesn't use insulin properly) and obesity-related diseases. You would be assigned to either an exercise group or a group that doesn't exercise. All participants will go through a 10% weight loss program, followed by a high-calorie diet to regain half of the lost weight. The study is looking for 46 participants between 18 and 40 years old with a BMI between 27-45 kg/m2 who don't regularly exercise. Success will be measured by changes in glucose tolerance, fat tissue fibrosis (scarring), and muscle capillarization (blood vessel growth). The current status of the study is unclear.

Study design

This is an interventional study with 46 planned participants. You would be randomly assigned to one of two groups: an exercise group or a no-exercise (control) group.

What's involved

You would undergo a series of metabolic tests before and after a 10% weight loss program, and again after a high-calorie diet to regain half of the lost weight. If in the exercise group, you would complete moderate intensity continuous exercise 4 days/week.

Compensation

Not stated in the trial record.

Follow-up

Primary endpoints are measured at 2 hours and 30 minutes after certain tests. The overall follow-up duration is not specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.