Atrial Fibrosis in Obstructive Sleep Apnea Patients: A Pilot Study

This pilot study is looking into whether obstructive sleep apnea (OSA) is linked to atrial fibrosis (scarring in the heart's upper chambers). Researchers will use a special MRI scan called Delayed Enhancement Magnetic Resonance Imaging (DE-MRI) to measure the amount of atrial fibrosis in people with OSA who have not been diagnosed with atrial fibrillation (a type of irregular heartbeat). You may be able to join if you are 18-75 years old and have mild, moderate, or severe OSA. The study aims to enroll 60 participants. The current status of the study is unclear, so it's not known if they are actively recruiting.

Study design
This is a cross-sectional pilot study involving 60 participants with obstructive sleep apnea and 5 control participants. It is not specified if the study is randomized or blinded.
What's involved
You will undergo a DE-MRI scan. Your demographic information, medical history, and previous polysomnography (sleep study) results will be collected.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint, percentage of atrial fibrosis, is measured at the baseline visit. No further follow-up is specified.

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NCT04814420

Atrial Fibrosis in Obstructive Sleep Apnea Patients: A Pilot Study

Recruiting
NAAges 18–75InterventionalPrevention
Tulane University
~60 participants
Updated 2026-06-15 on ClinicalTrials.gov
What's tested:Delayed enhancement magnetic resonance imaging (DE-MRI)

At a glance

Recruiting sites
3 of 3 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Percentage of atrial fibrosis in the left atrium measured by DE-MRI
Measured over Baseline visit
Atrial Fibrillation
Obstructive Sleep Apnea
3 sites across 1 states
Louisiana3
  • Amitabh Pandey, MD · PRINCIPAL_INVESTIGATOR · Tulane University School of Medicine

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Eligibility criteria

Inclusion

In this group, patients with AF and OSA who already have done MRI might be included.

Exclusion

History of chronic heart failure (LVEF \< 50%), AF, myocardial infarction, valvular disease.
Prior cardiac or chest surgery.
Other advanced pulmonary disease (severe Chronic Obstructive Pulmonary Disease (COPD) or asthma, pulmonary hypertension) or central sleep apnea.
Contraindications to DE-MRI (e.g. allergy to gadolinium, pacemakers, defibrillators (ICD's), other devices/implants contraindicated for MRI, glomerular filtration rate \<30 ml/min, etc.).
Pregnancy.
Inability to give informed consent.
  • Percentage of atrial fibrosis in the left atrium measured by DE-MRIBaseline visit

    DE-MRI purpose is to quantify the degree of atrial structural remodeling or fibrosis Left Atrial Volume Max on MRI measurement reflects atrial load to provide insight into atrial remodeling Left Atrial Volume Min on MRI is important for understanding atrial function, particularly its ability to contract and expel blood into left ventricle Left Atrial Volume Index on MRI is an indicator of left atrial enlargement compared to raw volume measurements Left Atrial Emptying Fraction on MRI is a measure of atrial contractile function. Higher LAEF indicates better atrial function, while lower values can signal impaired atrial mechanics Left Atrial Global Strain on MRI which is the percentage change in myocardial length along the long axis of the left atrium, is calculated using a formula averaging the individual longitudinal strain values from each segment of the myocardium, providing a comprehensive measure of myocardial deformation