Atrial Fibrosis in Obstructive Sleep Apnea Patients: A Pilot Study
This pilot study is looking into whether obstructive sleep apnea (OSA) is linked to atrial fibrosis (scarring in the heart's upper chambers). Researchers will use a special MRI scan called Delayed Enhancement Magnetic Resonance Imaging (DE-MRI) to measure the amount of atrial fibrosis in people with OSA who have not been diagnosed with atrial fibrillation (a type of irregular heartbeat). You may be able to join if you are 18-75 years old and have mild, moderate, or severe OSA. The study aims to enroll 60 participants. The current status of the study is unclear, so it's not known if they are actively recruiting.
- Study design
- This is a cross-sectional pilot study involving 60 participants with obstructive sleep apnea and 5 control participants. It is not specified if the study is randomized or blinded.
- What's involved
- You will undergo a DE-MRI scan. Your demographic information, medical history, and previous polysomnography (sleep study) results will be collected.
- Compensation
- Not stated in the trial record.
- Follow-up
- The primary endpoint, percentage of atrial fibrosis, is measured at the baseline visit. No further follow-up is specified.
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Atrial Fibrosis in Obstructive Sleep Apnea Patients: A Pilot Study
At a glance
Conditions
Where it's being run
3 sites across 1 statesStudy leadership
- Amitabh Pandey, MD · PRINCIPAL_INVESTIGATOR · Tulane University School of Medicine
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Percentage of atrial fibrosis in the left atrium measured by DE-MRIBaseline visit
DE-MRI purpose is to quantify the degree of atrial structural remodeling or fibrosis Left Atrial Volume Max on MRI measurement reflects atrial load to provide insight into atrial remodeling Left Atrial Volume Min on MRI is important for understanding atrial function, particularly its ability to contract and expel blood into left ventricle Left Atrial Volume Index on MRI is an indicator of left atrial enlargement compared to raw volume measurements Left Atrial Emptying Fraction on MRI is a measure of atrial contractile function. Higher LAEF indicates better atrial function, while lower values can signal impaired atrial mechanics Left Atrial Global Strain on MRI which is the percentage change in myocardial length along the long axis of the left atrium, is calculated using a formula averaging the individual longitudinal strain values from each segment of the myocardium, providing a comprehensive measure of myocardial deformation